International comparison of genomic variations for prognostic factors in chronic kidney disease

慢性肾脏病预后因素基因组变异的国际比较

• 批准号: 23406027
• 负责人: MATSUO Seiichi
• 金额: $ 12.06万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23406027/
• 关键词: ゲノムDNAメチル化; 末期腎不全; コホート研究; LUMA法; 炎症; 感染症; 国際研究者交流; スウェーデン; CKD stage5; 遺伝子多型

Inflammation is an established mortality risk factor in chronic kidney disease (CKD) patients and infection may contribution to induce inflammation. Our collaborating Nephrology group in Sweden showed that inflamed uremic Caucasian patients had signs of global DNA hyper-methylation. We have investigated that DNA hyper-methylation is linked to inflammatory markers including a marker of bacterial infections in Japanese CKD patients.Global DNA hyper-methylation was associated with ferritin and procalcitonin as a marker of bacterial infection, suggesting that inflammation induced by subclinical bacterial infection promoted DNA methylation. Moreover, Global DNA hyper-methylation was associated with near future inflammatory status, suggesting a possible axis between hyper-methylation status and present as well as future inflammatory status.These results strongly suggest that to control infection and immune dysfunction due to uremia may be important to induce inflammation in CKD patients.

炎症是慢性肾脏疾病（CKD）患者死亡的危险因素之一，感染可能诱发炎症。我们在瑞典合作的肾病学小组表明，炎症性尿毒症高加索患者有整体DNA超甲基化的迹象。我们研究了DNA超甲基化与炎症标志物相关，包括日本CKD患者的细菌感染标志物。整体DNA超甲基化与铁蛋白和降钙素原相关，这是细菌感染的标志，表明亚临床细菌感染诱导的炎症促进了DNA甲基化。此外，全球DNA超甲基化与近期的炎症状态相关，这表明超甲基化状态与当前以及未来的炎症状态之间可能存在轴。这些结果强烈提示控制尿毒症引起的感染和免疫功能障碍可能是CKD患者诱导炎症的重要因素。

项目成果

Autologous cell therapy for cisplatin-induced acute kidney injury by using non-expanded adipose tissue-derived cells

• DOI: 10.3109/14653249.2012.693157
• 发表时间: 2012-10-01
• 期刊: CYTOTHERAPY
• 影响因子: 4.5
• 作者: Yasuda, Kaoru;Ozaki, Takenori;Maruyama, Shoichi
• 通讯作者: Maruyama, Shoichi

Analysis of glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 expression in human diseased kidney.

• DOI: 10.1016/j.humpath.2010.09.015
• 发表时间: 2011-06
• 期刊: Human pathology
• 影响因子: 3.3
• 作者: Shoji Saito;Y. Murakumo;T. Tsuzuki;Atsushi Dambara;Takuya Kato;A. Enomoto;N. Asai;S. Maruyama;S. Matsuo;Masahide Takahashi

Overestimation of the risk of progression to end-stage renal disease in the poor prognosis’ group according to the 2002 Japanese histological classification for immunoglobulin A nephropathy

根据 2002 年日本免疫球蛋白 A 肾病组织学分类，高估了不良预后组进展为终末期肾病的风险

• DOI: 10.1007/s10157-013-0848-y
• 发表时间: 2013
• 期刊: Clinical and Experimental Nephrology
• 影响因子: 2.3
• 作者: Y. Miyazaki;T. Kawamura;K. Joh;H. Okonogi;K. Koike;Y. Utsunomiya;M. Ogura;M. Matsushima;M. Yoshimura;S. Horikoshi;Yusuke Suzuki;A. Furusu;T. Yasuda;Sayuri Shirai;T. Shibata;M. Endoh;M. Hattori;Y. Akioka;R. Katafuti;A. Hashiguchi;K. Kimura;S. Matsuo;Y. Tomino
• 通讯作者: Y. Tomino

ワークショップ2 基礎から臨床につながる補体学

工作坊2 补充学从基础到临床实践

• 发表时间: 2013
• 作者: 水野 正司;伊藤 恭彦;鈴木 康弘;清 祐実;丸山 彰一;松尾 清一
• 通讯作者: 松尾 清一

日本の膜性腎症患者における抗PLA2R自己抗体の陽性率

日本膜性肾病患者抗PLA2R自身抗体阳性率

• 发表时间: 2013
• 作者: 秋山 真一;尾崎 武徳;横山 仁;松尾 清一;今井 圓裕;丸山 彰一
• 通讯作者: 丸山 彰一