International comparison of genomic variations for prognostic factors in chronic kidney disease

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Inflammation is an established mortality risk factor in chronic kidney disease (CKD) patients and infection may contribution to induce inflammation. Our collaborating Nephrology group in Sweden showed that inflamed uremic Caucasian patients had signs of global DNA hyper-methylation. We have investigated that DNA hyper-methylation is linked to inflammatory markers including a marker of bacterial infections in Japanese CKD patients.Global DNA hyper-methylation was associated with ferritin and procalcitonin as a marker of bacterial infection, suggesting that inflammation induced by subclinical bacterial infection promoted DNA methylation. Moreover, Global DNA hyper-methylation was associated with near future inflammatory status, suggesting a possible axis between hyper-methylation status and present as well as future inflammatory status.These results strongly suggest that to control infection and immune dysfunction due to uremia may be important to induce inflammation in CKD patients.