The role of mcl-1 in pancreatic β-cell during differentiation and high glucose stimulation

mcl-1 在胰腺 β 细胞分化和高糖刺激过程中的作用

• 批准号: 18790282
• 负责人: SANO Makoto
• 金额: $ 2.32万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18790282/
• 关键词: 膵ラ氏島; β細胞; Mcl-1遺伝子; インスリン産生細胞; AR42J細胞; 糖負荷; Bcl-2ファミリー遺伝子; nesidioblastosis; インスリン産生

糖尿病には,膵ラ氏島のインスリン産生細胞(β細胞)が深く関わっている.本研究では,インスリン産生細胞の分化誘導モデルとしてAR42J細胞を用い,β細胞の分化過程と糖負荷刺激におけるアポトーシス抑制遺伝子Mcl-1の動態を解析した.その結果,β細胞への分化過程,ならびに高濃度の糖負荷刺激に伴って誘導されるアポトーシスの抑制に,Mcl-1遺伝子の発現が密接に関わっていることが明らかとなった.

Diabetes mellitus, diabetes, diabetes. In this study, the process of differentiation of AR42J cells and β-cell differentiation was studied. The process of differentiation of β-cells was induced by glucose loading. The inhibition of Mcl-1 was detected by dynamic analysis. The results showed that the process of β-cell differentiation was induced by high-level glucose stimulation, which was induced by high concentration of glucose, and that was inhibited by high-level glucose stimulation. The results showed that the β-cell differentiation process was in the process of β-cell differentiation, and the β-cell differentiation process was induced by high-level glucose stimulation. The results showed that the β-cell differentiation process was in the process of β-cell differentiation, and the β-cell differentiation process was induced by high-level glucose stimulation, which was induced by high-level glucose stimulation, and Mcl-1 was induced by high-glucose stimulation.

项目成果

Testicular Cancer Research Trends ; Expression of Bcl-2 family members in testicular germ cell tumors,Chapter II

睾丸癌研究趋势；

• 发表时间: 2007
• 作者: Sano M;Suzuki A;and Nemoto N
• 通讯作者: and Nemoto N

小児膵島細胞症(nesidioblastosis)におけるMcl-1遺伝子の発現分布

Mcl-1 基因在小儿胰岛细胞病（胰岛细胞增多症）中的表达分布

• 发表时间: 2007
• 作者: Sano M;Hayashi E;Murakami H;Kishimoto H;Fukuzawa R;and Nemoto N;佐野 誠,林 恵美子,村上仁彦,岸本宏志,福澤龍二,根本則道
• 通讯作者: 佐野 誠,林 恵美子,村上仁彦,岸本宏志,福澤龍二,根本則道

Mcl-1, an anti-apoptotic Bcl-2 family member, essentially overlaps with insulin-producing cells in neonatal nesidioblastosis

Mcl-1 是一种抗凋亡 Bcl-2 家族成员，在新生儿成纤维细胞增多症中与产生胰岛素的细胞本质上重叠

• 期刊: Virchows Archiv (In press)
• 作者: Sano M;Hayashi E;Murakami H;Kishimoto H;Fukuzawa R;and Nemoto N
• 通讯作者: and Nemoto N

Mcl-1, an anti-apoptotic Bcl-2 family member, essentially overlaps with insulin- producing cells in neonatal nesidioblastosis

Mcl-1 是一种抗凋亡 Bcl-2 家族成员，在新生儿成纤维细胞增多症中与胰岛素生成细胞本质上重叠

• 发表时间: 2008
• 期刊: Virchows Archiv
• 影响因子: 3.5
• 作者: Sano M;Hayashi E;Murakami H;Kishimoto H;Fukuzawa R;and Nemoto N
• 通讯作者: and Nemoto N

Testicular Cancer Research Trends : Expression of Bcl-2 family members in testicular germ cell tumors

睾丸癌研究趋势：Bcl-2家族成员在睾丸生殖细胞肿瘤中的表达

• 作者: Sano M;Suzuki A;Nemoto N
• 通讯作者: Nemoto N