SKELETAL MUSCLE: REVERSIBLE TEMEPERATURE-INDUCED UNCOUPLING OF CONTRACTION FROM THE ACTIVATOR Ca2+ AND TUBULAR SYSTEM ROLES IN MUSCLE FUNCTION REGULATION

骨骼肌：温度诱导的可逆性收缩与激活剂 Ca2 的解耦以及肌肉功能调节中管状系统的作用

• 批准号: DP0345329
• 负责人: Em/Prof Dimitrie Stephenson
• 金额: $ 33.84万
• 依托单位: La Trobe University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-02-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0345329
• 关键词: SKELETAL; MUSCLE; REVERSIBLE; TEMEPERATURE; INDUCED

Skeletal muscles represent the largest organ in the body of vertebrates and are responsible for major functions including maintaining posture and locomotion. Skeletal muscles are also a major source of heat production. The project focuses on temperature-induced effects on the ability of the skeletal muscle to contract in warm blooded animals, including marsupials, and on the complex roles played by a cellular structure unique to the muscle fibre, the tubular system, with respect to regulation of muscle function at physiological temperatures. The project will test hypotheses that will have far-reaching implications for muscle physiology, cell biology and evolutionary biology.

骨骼肌是脊椎动物体内最大的器官，负责维持姿势和运动等主要功能。骨骼肌也是产生热量的主要来源。该项目的重点是温度对温血动物（包括有袋动物）骨骼肌收缩能力的影响，以及肌肉纤维特有的细胞结构（管状系统）在生理温度下调节肌肉功能方面所发挥的复杂作用。该项目将测试对肌肉生理学，细胞生物学和进化生物学具有深远影响的假设。