PREVENTIVE RESEARCH OF DIETARY ENVIRONMENT FACTORS WHICH ARE RELATED TO GENERATION AND PROGRESSION OF PROSTATE CANCER IN JAPANESE MALES

由于前列腺癌的发病率和死亡率随着西化社会生活在日本的蔓延而增加，因此迫切需要从分子预防研究的角度探讨微小隐匿性前列腺癌的进展与饮食环境因素之间的关系。本研究采用冷冻血清测定了日本男性的残粒样胆固醇（RLP-C）和RLP-甘油三酯（RLP-TG），作为生活方式西方化的指标。25例经至少3次连续筛查确诊为前列腺癌且基线PSA水平低于4 ng/ml的患者（病例组）和25例经年龄校正和基线PSA校正的无前列腺癌男性（对照组），均在1992年至2005年期间参加了基于人群的前列腺癌筛查。在两组的初始筛选访视时，在末次筛选访视时，使用血清样本测量RLP-C和RLP-TG。 ...更多信息 对照组和病例组在确诊时。病例组和对照组的平均RLP-C水平在初始筛选时分别为33.9mg/dl和26.8mg/ml，在末次筛选时分别为27.6mg/dl和20.8mg/dl。两次筛选访视时病例组的平均血清RLP-Cs均高于对照组，但差异无统计学意义。病例组和对照组的平均RLP-TG在初始筛选时分别为46.2 mg/dl和44.6 mg/dl，在末次筛选时分别为48.6 mg/dl和39.1 mg/dl。病例组的平均血清RLP-TG水平从初筛到末次筛选均升高，而对照组无升高。然而，即使在最后一次筛查时，病例组和对照组之间的RLP-TG水平也没有显著差异。本研究未显示病例组和对照组在初始和末次筛选访视时血清RLP-C和RLP-TG的显著差异，本研究仍可能显示血清残脂蛋白持续升高与前列腺癌发生之间的关系。少

Because the incidence and mortality rates of prostate cancer have increased with westernized-social life spreading in Japan, it is urgently needed to investigate the relationship between progression of minimal occult prostate cancer and dietary environment factors in the molecular preventive research point of view. The present study measured remnant-like particles-cholesterol (RLP-C) and RLP-triglyceride (RLP-TG) using frozen serum as an index to westemization of life-style in Japanese males. Twenty five cases diagnosed with prostate cancer after at least 3 consecutive screening with baseline PSA levels lower than 4ng/ml (case group) and age-adjusted and baseline-PSA-adjusted 25 men without prostate cancer (control group), who participated in the population-based screening for prostate cancer between 1992 and 2005, were enrolled in the present study. RLP-C and RLP-TG were measured using serum samples at the time of initial screening visit for both groups, at the last screening visit fo … More r control group and at the time of diagnosis for case group. The mean RLP-C levels in case and control groups, respectively, were 33.9mg/dl and 26.8mg/ml at the initial screening, and 27.6mg/dl and 20.8mg/dl at the last screening. The mean serum RLP-Cs in case group were higher than those in the control group at both screening visits, but there was no significant difference. The mean RLP-TG in the case and control groups, respectively, were 46.2 mg/dl and 44.6 mg/dl at the initial screening, and 48.6 mg/dl and 39.1 mg/dl at the last screening. The mean serum RLP-TG levels increased from initial to last screening in the case groups, but not did in the control groups. However, there was no significant difference in the RLP-TG levels even at the last screening between the case and control groups. The present study did not show significant differences in the serum RLP-C and RLP-TG between the case and control group both at the initial and last screening visits, the present study may still show the possibility of relationship between continuous increase in serum remnant lipoprotein and developing prostate cancer. Less