Genetic analysis of susceptibility to prostate cancer

长期以来，人们一直认为前列腺癌的发生与遗传因素有关。西方国家已经报道了使用大规模遗传性前列腺癌家系进行遗传分析的报道。在日本，还没有关于家族性前列腺癌的基因分析的报道。在这项研究中，我们对与前列腺癌有关的高外显和低外显基因进行了遗传分析。首先，我们确定了已报道的前列腺癌易感性候选基因RNASEL基因和ELAC2/HPC2基因的基因类型。在HPC2基因中，A1A541Thr基因型仅见于前列腺癌。在RNASEL基因中，Asp541Glu基因型与前列腺癌的发生、发展相关，连锁分析显示1p36、D1S2667和8p23 D8S550与前列腺癌的发生、发展有显著关联。1p36基因座与CAPB基因座一致，8p23基因座与MRS1、FDFT1基因一致。我们现在正试图找出这些区域与前列腺癌风险之间的关联。

Involvement of genetic factors to prostate cancer development has long been proposed. Genetic analysis using large scale hereditary prostate cancer pedigrees has been reported from Western countries. In Japan, no reports have been published on genetic analysis of familial prostate cancer. In this study, we performed genetic analysis of high penetrance and low penetrance genes involved in prostate cancer. First, we determined the genotypes of RNASEL gene and ELAC2/HPC2 genes those have been reported as candidate genes to prostate cancer susceptibility. In HPC2 gene, A1a 541Thr genotype was exclusively found in prostate cancer. In RNASEL gene, Asp541Glu genotype was associated with prostate cancer development and progression.Linkage analysis showed that 1p36, D1S2667 and 8p23 D8S550 were significantly associated with suggestive linkage. 1p36 locus is coincident to CAPB locus and 8p23 locus is coincident to MRS1 and FDFT1 genes. We are now trying to find the association of these regions to prostate cancer risk.