Impact of endocrine environment on the development, biological features and progression of prostate cancer.

西化饮食引起的血清胆固醇升高可能影响人体内矿物皮质激素浓度及性激素环境的变化。在本研究中，我们探讨了血清性激素与促进前列腺癌的相关性。一项病例对照研究表明，诊断为前列腺癌的患者数年前的血清孕烯醇酮（P5）水平明显高于无临床表现前列腺癌的男性，而雌二醇和11-脱氧皮质酮水平明显低于无临床表现前列腺癌的男性。转换酶CYP11A1的加速可能在导致这种特定的内分泌特征和随后的癌症发展中发挥一定作用。

Increased serum cholesterol concentration due to westernized diet may affect mineral corticoids concentration and following changes in sex hormone environment in human. In the present study, we investigated correlation between serum sex hormones and promotion of prostate cancer. A case control study demonstrated that patients diagnosed with prostate cancer had significantly higher serum pregnenolone (P5) level and lower both estradiol and 11-deoxycorticosterone levels in the serum taken several years ago compared with men without clinically manifested prostate cancer. An acceleration of converting enzyme, CYP11A1, may play some role to lead such a specific endocrine feature and following cancer development.