Evaluation of fetal blood pressure changes during intrapartum period : basic and clinical researches

产时胎儿血压变化的评估：基础与临床研究

• 批准号: 18591805
• 负责人: SAMESHIMA Hiroshi
• 金额: $ 2.5万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591805/
• 关键词: Electro-mechanical difference; Fetal blood pressure; Fetal heart rate monitoring; non-invasive monitoring; Fetal oxygen saturation; electro-mechanical difference; 胎児酸素飽和度; electro-mechanical; 神経学的予後

Background : From our previous studies, we found that electro-mechanical difference in the fetus is reciprocal to blood pressure changes in utero.Materials and methods : After IRB approval, we introduced this technique to clinical practice to continuously evaluate fetal blood pressure changes during labor and delivery. After informed consent was obtained from each of the 18 mothers, we placed an electrode on the scalp for fetal electrocardiogram and a SpO2 probe on the cheek, after rupture of the membranes.Results : Electro-mechanical difference was available in all cases. There was no technique-related abnormality in the conduction of labor. All infants had umbilical arterial pH values > 7.2 and normal neurological outcome. Among the 15 cases with 1-hour or more monitoring duration, the time difference became shortening in 7 cases, extending in 2, and stable in 6. Comparing the shortening and stable groups, incidence of severe variable deceleration was significantly increased in the shortening group, suggesting the reflection of catecholamine release leading possibly to blood pressure increases.Conclusions : These findings suggest that this technique is promising and practically applicable to clinical use to supplement fetal heart rate monitoring such that to decrease false positive rate of non-reassuring fetal status.

背景资料：从我们以前的研究中，我们发现，胎儿的机电差异是可逆的血压变化在utero.Materials和方法：IRB批准后，我们介绍了这项技术的临床实践，以不断评估胎儿血压变化在劳动和交付。知情同意后，从18位母亲，我们放置了一个电极在头皮上的胎儿心电图和一个SpO2探头的脸颊，破膜后。在分娩过程中没有技术相关的异常。所有婴儿的脐动脉pH值> 7.2，神经功能正常。15例监测时间大于或等于1 h的病例中，7例时间差缩短，2例时间差延长，6例时间差稳定。缩短组和稳定组相比，发生率严重可变减速显着增加缩短组，这表明反映的儿茶酚胺释放可能导致血压increases.Conclusions：这些研究结果表明，这项技术是有前途的，实际上适用于临床使用，以补充胎儿心率监测，以减少假阳性率的非放心胎儿状态。

项目成果

Risk factors for perinatal deaths in Southern Japan:Population-based analysis from 1998 to 2005

日本南部围产期死亡的危险因素：1998 年至 2005 年基于人口的分析

• 发表时间: 2007
• 期刊: Early Hum Dev 84(5)
• 作者: Sameshima H;Ikenoue T;for the Miyazaki Perinatal Data Group
• 通讯作者: Ikenoue T;for the Miyazaki Perinatal Data Group

Antithrombin improves fetal condition in women with severe pre-eclampsia before 32 weeks of gestation; a randomized, double-blind, placebo-controlled trial.

抗凝血酶可改善妊娠 32 周前患有严重先兆子痫的女性的胎儿状况；

• 发表时间: 2008
• 期刊: J Obstet Gynaecol Res 34(1)
• 作者: Sameshima H;Kodama Y;Ikenoue T;Kajiwara Y.
• 通讯作者: Kajiwara Y.

胎児心拍数による中枢神経系の評価の意義と限界

使用胎心率评估中枢神经系统的意义和局限性

• 发表时间: 2006
• 期刊: 周産期医学 36巻10号
• 作者: 大口 昭英;松原 茂樹;鮫島 浩
• 通讯作者: 鮫島 浩

Clinical application of pulse transit time and correlation with intrapartum fetal heart rate monitoring.A preliminary study of 18 full-term infants

脉搏传导时间及其与产时胎心率监测相关性的临床应用——18例足月儿的初步研究

• 期刊: Reproductive Sciences
• 影响因子: 2.9
• 作者: Kawagoe Y;Sameshima H;Ikenoue T.
• 通讯作者: Ikenoue T.

Developmental effects on neonatal mortality and subsequent cerebral palsy in infants exposed to intrauterine infection

• DOI: 10.1016/j.earlhumdev.2006.09.040
• 发表时间: 2007-08-01
• 期刊: EARLY HUMAN DEVELOPMENT
• 影响因子: 2.5
• 作者: Sameshima, Hiroshi;Ikenoue, Tsuyomu
• 通讯作者: Ikenoue, Tsuyomu