Effect of magnesium on fetal circulatory responses to acute hypoxemia

镁对胎儿急性低氧血症循环反应的影响

基本信息

  • 批准号:
    09671700
  • 负责人:
  • 金额:
    $ 1.92万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    1997
  • 资助国家:
    日本
  • 起止时间:
    1997 至 1998
  • 项目状态:
    已结题

项目摘要

Effect of magnesium sulfate on fetal circulatory responses to acute hypoxemia was studied with a "chronic preparation" goat model.Acute hypoxemia causes fetal heart rate (FHR) deceleration with an increase in fetal arterial blood pressure (BP). Hypoxemia with a continuous magnesium infusion masks these fetal responses and shows no changes in FHR or BP.Four-hours magnesium infusion decreases baseline FHR, incidence of acceleration of FHR, and baseline variabilities. Acute hypoxemia significantly increases FHR variabilities, which are not blunted by magnesium. Catecholamines are increased by hypoxemia as well as hypoxemia with magnesium.Blood flow is measured by a colored microsphere method. From the pre-hypoxemic level, hypoxemia significantly increases blood flow to the cerebral cortex, midbrain, cerebellum, medulla, and heart. Magnesium further increases blood low to these organs, and this increase to the cerebral cortex achieves statistical significance.To better understand magnesium neuroprotective effect, we use 7-day-old rats model (unilateral carotid artery ligation with 2 hours hypoxia). Pretreatment of magnesium before the hypoxic-ischemic insult shows neuroprotective effects in all the part of the brain, but statistical significance is limited to the cerebral cortex.These results reveal that magnesium has neuroprotective effects on the fetus (and newborn), and that increases in blood flow to the brain and heart with magnesium may account for the neuroprotective effects.
通过“慢性准备”山羊模型研究了硫酸镁对胎儿对急性低氧血症的循环反应的影响。急性低氧血症导致胎儿心率(FHR)减慢,同时胎儿动脉血压(BP)升高。连续镁输注引起的低氧血症掩盖了这些胎儿反应,并且胎心率或血压没有变化。四小时镁输注会降低基线胎心率、胎心率加速的发生率和基线变异。急性低氧血症显着增加胎心率变异性,而镁不会减弱这种变异性。儿茶酚胺会因低氧血症以及镁低氧血症而增加。血流量通过有色微球法测量。从低氧血症前的水平开始,低氧血症显着增加了大脑皮层、中脑、小脑、延髓和心脏的血流量。镁进一步增加了这些器官的血流量,而这种增加对大脑皮层的血流量具有统计学意义。为了更好地了解镁的神经保护作用,我们使用7日龄大鼠模型(单侧颈动脉结扎缺氧2小时)。在缺氧缺血性损伤之前进行镁的预处理显示出对大脑所有部分的神经保护作用,但统计意义仅限于大脑皮层。这些结果表明,镁对胎儿(和新生儿)具有神经保护作用,并且镁增加流向大脑和心脏的血流量可能是神经保护作用的原因。

项目成果

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专利数量(0)
Sameshima H.,Ikenoue T.,Kamitomo M.,Sakamoto H.: "Effects of magnesium sulfate on the fetal heart rate responses during acute hypoxemia in goats" J.Society for Gynecol.Invest.3. 235-240 (1996)
Sameshima H.、Ikenoue T.、Kamitomo M.、Sakamoto H.:“硫酸镁对山羊急性低氧血症期间胎心率反应的影响”J.Society for Gynecol.Invest.3。
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Sameshima H,Ikenoue T,Kamitomo M,Sakamoto H: "Pre-treatment with magnesium sulfate and post-treatment deteriorates hypoxic-ischemic brain injury in 7-day-old rats." Am J Obstet Gynecol. (in press). (1999)
Sameshima H、Ikenoue T、Kamitomo M、Sakamoto H:“硫酸镁预处理和后处理会加重 7 日龄大鼠的缺氧缺血性脑损伤。”
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Sameshima H.,Ikenoue T.,Kamitomo M.,Sakamoto H.: "Pre-treatment with magnesium sulfate protects and post-treatment deteriorates hypoxic-ischemic brain injury in 7-day-old rats" Am.J.Obstet.Gynecol.(in press). (1999)
Sameshima H.、Ikenoue T.、Kamitomo M.、Sakamoto H.:“硫酸镁预处理可保护 7 日龄大鼠的缺氧缺血性脑损伤,治疗后会恶化”Am.J.Obstet.Gynecol。
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Sameshima H,Ikenoue T,Kamitomo M,Sakamoto H: "Effects of magnesium sulfate on the fetal heart rate responses during acute hypoxemia in goats." J Society for Gynecol Invest. 3. 235-40 (1996)
Sameshima H、Ikenoue T、Kamitomo M、Sakamoto H:“硫酸镁对山羊急性低氧血症期间胎心率反应的影响”。
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    0
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Hiroshi Sameshima: "Effects of magnesium sulfate on the fetal heart rate vesponses during acute hypoxemia in goats" J.Society for Gynecol. Invest.3. 235-240 (1996)
Hiroshi Sameshima:“硫酸镁对山羊急性低氧血症期间胎心率反应的影响”J.Society for Gynecol。
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SAMESHIMA Hiroshi其他文献

SAMESHIMA Hiroshi的其他文献

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{{ truncateString('SAMESHIMA Hiroshi', 18)}}的其他基金

Parasympathetic nerve activity and hypoxic-ischemic brain damage in the developing fetus
发育中胎儿的副交感神经活动和缺氧缺血性脑损伤
  • 批准号:
    24592476
  • 财政年份:
    2012
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Evaluation of fetal blood pressure changes during intrapartum period : basic and clinical researches
产时胎儿血压变化的评估:基础与临床研究
  • 批准号:
    18591805
  • 财政年份:
    2006
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Basic and clinical investigations on fetal blood pressure monitoring in labor by the difference in electrocardiogram and pulse oxymetry.
心电图和脉搏血氧饱和度差异监测临产胎儿血压的基础和临床研究。
  • 批准号:
    13671734
  • 财政年份:
    2001
  • 资助金额:
    $ 1.92万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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A basic study on the effects of fetal circulation have on the placenta oxygenation dynamics by near-infrared spectroscopy
近红外光谱法探讨胎儿循环对胎盘氧合动态影响的基础研究
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    20791149
  • 财政年份:
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