A clinicoanatomical study of the novel nerve fibers linked to mechanisms of female pelvic organ prolapse

与女性盆腔器官脱垂机制相关的新型神经纤维的临床解剖学研究

• 批准号: 18591853
• 负责人: KOYAMA Masayasu
• 金额: $ 2.43万
• 依托单位: Tazuke Kofukai Medical Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18591853/
• 关键词: pelvic organ prolapse; pubocervical fascia; rectovaginal fascia; urinary incontinence; nerve distribution; perineal body; levator ani nerve; sacrosninous ligament; 直腸腟筋膜; 仙棘靱帯; 性器脱; 骨盤底臓器脱; 節後性交感神経束; S100抗体; Tyrosine Hydroxylase抗体; 骨盤神経叢

Descent and dysfunction of a pelvic floor organ have caused degradation of quality of life of a senior citizen with progress of aging society, and consequently, it interferes with successful aging. As for the muscle of support mechanism of pelvic floor organs, analysis of anatomy of the fascia, the connective tissue and the innervation will be fundamental and important data to develop the high quality therapy that took urination, evacuation and reproductive function into consideration. The aim of the study was to anatomically identify nerve fibers located around vaginal wall associated with the pathogenesis of pelvic organ prolapse. The novel nerve fibers immunohistochemically identified in the anterior vaginal wall are different from those of the common nervous system or the pelvic floor and are associated with the pathogenesis of urethral hypermobility. The nerve fiber immunohistochemically identified in this study was present inward than nerve bundle of pelvic splanchnic nerves repo … More rted previously and originated from the cranial part of the pelvic plexus, and appeared to terminate at the urethral smooth muscles. These novel nerve fibers will play an important role for an urethra support function. In the present year, we demonstrated that they occurred in the postjunctional sympathetic nerve immunohistochemically stained with S-100 and tyrosin hydroxylase antibody more from the head side of pelvic plexus in this year and identified that it was the nerve fascicle which continued in urethra plain muscle. Furthermore, we analyzed the posterior vaginal wall structure. The fascial configuration of posterior vagina which is connected pubocervical fascia, uterosacral ligament and paracervical ring wall was present between vagina and rectum as a rich plate of elastic fiber, but it was often thin and often interrupted. The central tendon of perineum (perineal body) connected to rectovaginal fascia offered anchoring apparatus with fibromuscular elasticity of 3-15mm long to superior vagina to 10-30mm long in the outside lower part. Pudendal nerve divergence is granted along inferior margin and breakdown by episiotomy might be concerned about. Finally I observed that a pelvic splanchnic nerve and levator ani muscle nerve ran locus of ischial spine inside 18.0mm over sacrospinous ligament, 12-26mm bottom at ischial spine bottom and enters a muscle in front of outside 40-55mm in coccyx. Less

随着老龄化社会的发展，骨盆底器官的下降和功能障碍已经导致老年人生活质量的下降，因此，它干扰了成功的衰老。对于盆底器官的支撑机制肌肉，分析其筋膜、结缔组织和神经支配的解剖学，将是制定兼顾排尿、排泄和生殖功能的高质量治疗方法的基础和重要资料。本研究的目的是从解剖学上确定阴道壁周围与盆腔器官脱垂发病机制相关的神经纤维。新的神经纤维在阴道前壁的化学鉴定是不同的普通神经系统或骨盆底，并与尿道过度活动的发病机制。本研究中的神经纤维在化学上比盆内脏神经的神经束更向内。 ...更多信息 起源于盆丛的头侧部，似乎终止于尿道平滑肌。这些新的神经纤维将在尿道支持功能中发挥重要作用。本年度我们用S-100和酪氨酸羟化酶抗体免疫组化染色证实，它们发生在盆丛头侧较多的连接后交感神经，并确定它是延续于尿道平滑肌的神经束。此外，我们还分析了阴道后壁的结构。阴道后壁筋膜连接耻骨颈筋膜、宫骶韧带和肛旁环壁，在阴道与直肠之间呈弹性纤维丰富的板状结构，但常较薄，常中断。会阴中央腱（会阴体）与直肠阴道筋膜相连，为上级阴道提供3- 15 mm长的纤维肌弹性锚定器，外下部10- 30 mm长。阴部神经的分支被允许沿着下缘，可能会被会阴切开术破坏。最后观察到盆内脏神经和提肛肌神经在骶棘韧带上方18.0mm内、坐骨棘底部12- 26 mm处走行于坐骨棘的轨迹，并在尾骨外侧40- 55 mm处入肌。少

项目成果

Histological reassessment of rectovaginal septum in Japanese elderly women for surgical repair against posterior vaginal defect

日本老年女性直肠阴道隔膜的组织学重新评估，用于修复后阴道缺损

• 发表时间: 2007
• 作者: 古山将康;高井由紀;溝口静子;勝矢聡子;濱田啓義;熊倉英利香;西岡良泰;松下克子;永野忠義;矢野樹里;小早川達;古山将康;三輪高喜;Sen,K
• 通讯作者: Sen,K

Involvement of RelA-associated inhibitor in regulation of trophoblast differentiation via interaction with transcriptional factor specificity protein-1

RelA 相关抑制剂通过与转录因子特异性蛋白 1 相互作用参与调节滋养层分化

• 发表时间: 2007
• 期刊: Endocrinology 14
• 作者: Minekawa;R
• 通讯作者: R

Mouse model of human infertility: Transient and local inhibition of endometrial STAT‐3 activation results in implantation failure

• DOI: 10.1016/j.febslet.2006.04.029
• 发表时间: 2006-05
• 期刊: FEBS Letters
• 影响因子: 3.5
• 作者: H. Nakamura;T. Kimura;S. Koyama;K. Ogita;T. Tsutsui;K. Shimoya;T. Taniguchi;M. Koyama;Y. Kaneda-Y

Simple and highly efficient method for transient in vivo gene transfer to mid-late pregnant mouse uterus.

简单高效的体内基因瞬时转移至中晚期妊娠小鼠子宫的方法。

• 发表时间: 2006
• 期刊: J Reprod Immunol 70(1-2)
• 作者: Koyama;S.;T.Kimura;K.Ogita;H.Nakamura;C.Tabata;K.Md Abu Hadi Noor Ali;K.Temma-Asano;K.Shimoya;T.Tsutsui;M.Koyama;Y.Kaneda;Y.Murata
• 通讯作者: Y.Murata

前膣壁下垂に対するプロリンソフトメッシュを用いた非固定式前膣壁形成術

使用脯氨酸软网进行非固定阴道前壁成形术治疗阴道前壁下垂

• 发表时间: 2006
• 期刊: 産婦人科の実際 55(13)
• 作者: 古山将康;高井由紀;溝口静子;勝矢聡子;濱田啓義;熊倉英利香;西岡良泰;松下克子;永野忠義;矢野樹里
• 通讯作者: 矢野樹里