Evaluation of liver damage by direct pulp capping and development of functional materials for pulp capping with biocompatibility and tissue degeneration

直接盖髓肝损伤评价及具有生物相容性和组织退变功能的盖髓功能材料的开发

• 批准号: 18592105
• 负责人: NAKAMURA Mariko
• 金额: $ 2.57万
• 依托单位: Junsei Junior College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592105/
• 关键词: polysaccharide; photo-crosslinkable gelatin; direct pulp capping; 天然多糖類; ゼラチン誘導体; 天然多糖; カルシウム塩; Fibrinogen; Thrombin

The photo-crosslinkable gelatin and phosphopullulan was employed as direct pulp capping method in dental field. Cavities with the exposed pulp area were prepared of first molars in rats. The cavity was formed using a 1/4 round bar and the pulp was eroded. The prepared cavity was washed reciprocally with 10% sodium hypochlorite and 3% hydrogen peroxide. All cavities were divided into three groups. The exposed pulps were covered with photo-crosslinkable gelatin preparation, phosphopullulan preparation and covered with conventional calcium hydroxide preparation. Then the cavities covered with photo-crosslinkable gelatin preparation were photo-irradiated. The margins of the treated areas of the molars were sealed with a protect liner. The animals were sacrificed at 1 weeks and 2 weeks after operation. In three groups, the capped treated teeth were observed at 1 and 2 weeks after operation. By 1 week after cavity preparation, the coalescence of inflammatory cells was observed subjacent to the exposed site of the dental pulp in the calcium hydroxide preparation, photo-crosslinkable gelatin preparation and phosphopullulan preparation -treated teeth. We found less inflammatory response when the cavities were treated with photo-crosslinkable gelatin preparation and phosphopullulan preparation. By 2 week after cavity preparation, the calcium hydroxide preparation and phosphopullulan preparation promote calcification. The effect of photo-curable gelatin and phosphopullulan was investigated for direct pulp capping.

在牙科领域中，直接盖髓的方法是采用光致交联型明胶和磷灰石。制备大鼠第一磨牙牙髓区裸露的窝洞。空洞是用1/4圆棒形成的，牙髓被侵蚀。准备好的空洞用10%次氯酸钠和3%过氧化氢交替清洗。将所有空洞分为三组。暴露的牙髓分别用光交联型明胶制剂、普鲁兰磷脂制剂和常规氢氧化钙制剂覆盖。然后用可光交联性明胶制剂覆盖的空洞进行光照射。磨牙治疗区域的边缘用保护衬里封闭。分别于术后1周和2周处死动物。三组分别于术后1周和2周取冠处理牙进行观察。窝洞预备后1周，氢氧化钙、光交联明胶、磷灰石处理牙牙髓裸露部位附近可见炎性细胞聚集。光交联型明胶制剂和普鲁兰磷脂制剂处理空洞时，炎症反应较轻。在空洞预备后2周，氢氧化钙和磷灰石促进钙化。研究了光固化明胶和普鲁兰用于直接盖髓的效果。

项目成果

Effect of 4-MET- and 10-MDP-based primers on resin bonding to titanium

• DOI: 10.4012/dmj.25.120
• 发表时间: 2006-03-01
• 期刊: DENTAL MATERIALS JOURNAL
• 影响因子: 2.5
• 作者: Tsuchimoto, Youhei;Yoshida, Yasuhiro;Kuboki, Takuo
• 通讯作者: Kuboki, Takuo

生体硬組織接着用キット

生物硬组织粘附套件

• 发表时间: 2011