Detection of nano-controlled molecular interaction of functional monomers at adhesive interfaces for hard tissue reconstruction

虽然龋齿/骨折的牙齿可以重建微创和几乎看不见的使用粘合剂技术，牙科复合材料修复的临床寿命仍然太短。水吸附被认为是生物材料-牙齿结合不稳定的主要原因。然而，界面降解的实际机制远未被理解。在这里，我们报告如何纳米控制的分子相互作用在生物材料的硬组织界面可以提高债券的耐久性。使用对羟基磷灰石中的钙具有强化学亲和力的功能单体对于长期耐久性至关重要。相关的X-射线衍射和固态核磁共振揭示了一个时间依赖性的分子相互作用在界面上与稳定的离子键形成的单体羟基磷灰石竞争的时间与沉积的不太稳定的磷酸钙盐。先进的牙齿-生物材料相互作用模型不仅可以深入了解键降解的机制，而且还为开发更持久的牙齿重建功能单体提供了基础。

Although decayed/fractured teeth can be reconstructed minimally invasively and nearly invisibly using adhesive technology, the clinical longevity of dental composite restorations is still too short. Water sorption is thought to be the principal cause of destabilization of the biomaterial-tooth bond. However, the actual mechanisms of interfacial degradation are far from understood. Here we report how nano-controlled molecular interaction at the biomaterial-hard tissue interface can improve bond durability. The use of functional monomers with a strong chemical affinity for the calcium in hydroxyapatite is essential for long-term durability. Correlative X-ray diffraction and solid-state nuclear magnetic resonance disclosed a time-dependent molecular interaction at the interface with stable ionic bond formation of the monomer to hydroxyapatite competing in time with the deposition of less stable calcium phosphate salts. The advanced tooth-biomaterial interaction model gives not only an insight into the mechanisms of bond degradation, but also provides a basis to develop functional monomers for more durable tooth reconstruction.