Next-generation dental resins which scavenge and immobilize endocrine disruptors by themselves

本研究的目的是发明含有Bis-GMA且绝对安全的下一代牙科树脂。介绍了混合具有高双酚A清除活性的活性氧化铝填料抑制双酚A洗脱的基本技术。用高效液相色谱法分析了各种商业双- gma单体。单体中Bis-GMA的含量约为50%，而Bis-GMA的异构体Iso-Bis-GMA含量约为25%。因此，我们发现商业的双- gma单体含双- gma异构体约80%。以氯仿为流动相，用硅胶柱层析法对商品Bis-GMA进行处理，得到纯度为20% ~ 30%的Bis-GMA主成分。将纯Bis-GMA与单体引发剂和填充剂结合制备化学固化树脂和可见光固化树脂。固化树脂的各种性能表明，它对双酚a等杂质的清除和固定化很有帮助。为了考察活性氧化铝填料对双酚A的自清除和自固定化性能，制备了多种不同组成的可见光固化复合树脂。通过在双酚A - gma复合材料中加入50%的碱性活性氧化铝，对双酚A进行了有效的清除和固定化。通过对固化树脂各种性能的测量，证明了活性氧化铝的引入是有效的，尽管还有进一步改进的空间。

The aim of the present investigation was to invent next-generation dental resins which contain Bis-GMA and is absolutely safe. The fundamental techniques to suppress the bisphenol A elution by mixing activated alumina fillers with high bisphenol A-scavenging activity were presented.1. Various commercial Bis-GMA monomers were analyzed by HPLC. Bis-GMA content of the monomers was about 50 % and approximately 25 % of Iso-Bis-GMA, an isomer of Bis-GMA, was present. Therefore, it was found that commercial Bis-GMA monomers contained about 80 % of Bis-GMA including isomers. Pure Bis-GMA main component was obtained in 20 to 30 % yield by silica gel column chromatography treatment of commercial Bis-GMA using chloroform as mobile phase.2. Chemical-curing and visible-light-curing resins were prepared by combining pure Bis-GMA with comonomer initiator, and filler. Various properties of cured resins revealed that it is quite helpful to scavenge and immobilize impurities such as bisphenolA in a Bis-GMA composite.3. In order to evaluate self-scavenging and self-immobilizing performance for bisphenol A of activated alumina fillers, a lot of experimental visible-light-curing composite resins with different composition were prepared. Bisphenol A was effectively scavenged and immobilized by introducing 50 wt% of basic activated alumina into Bis-GMA composites. Based on the measurements of various properties of cured resins, the introduction of activated alumina was proved effective, although there is some room for further improvement.