Microanalysis and leaching behavior of bisphenol A in dental materials

牙科材料中双酚A的微量分析及浸出行为

• 批准号: 10671821
• 负责人: KADOMA Yoshinori
• 金额: $ 2.11万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 1999
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671821/
• 关键词: Bisphenol A; Dental material; Analysis

The purposes of this study is to establish the method for microanalysis of bisphenol A contained in dental resins and then to ascertain whether bisphenol A is produced from unpolymerized monomers by decomposition reactions, etc. The evaluation of the possible reduction in bisphenol A amounts during polymerization was also chosen as the subject of the study.1. Microanalysis of bisphenol A amountsQuartz containers were used for microanalysis of bisphenol A amounts in order to eliminate the contamination with alkali metal ions as effectively as possible. A ratio of methanol/water=80/20 is most suitable for mobile phase of methanol-water mixture and a ratio of acetonitrile/water=60/40 for that of acetonitrile-water mixture. Microanalytical methods with the optimal design were established according to the properties of various test specimens.2. Bisphenol A release from bisphenol A related compounds caused by their decompositionBis-DMA was quite easily decomposed into bisphenol A under the a … More cidic or basic environment. On the other hand, the formation of bisphenol A from BHP was not observed, although Bis-GMA was decomposed into BHP which is an intermediate formed during hydrolysis. From the facts described above, it was concluded that there is little possibility of the production of bisphenol A from Bis-GMA, since BHP intermediate in hydrolysis is extremely stable.3. Interaction of bisphenol A with radicals formed during the cure of resinsInduction period increased with an increase in additional amounts of bisphenol A when 2,2'-azobis(isobutyronitrile) was used as an initiator. This revealed that bisphenol A is a typical polymerization inhibitor. Bisphenol A produced longer induction periods than hydroquinone in the polymerization initiated by benzoyl peroxide (BPO), which indicated that the former acts as an inhibitor more effectively than the latter in the presence of BPO. It was supposed that bisphenol A is no longer present in dental resins at the start of their curing, since bisphenol A contained in resins as an impurity is consumed by the reaction with initiator radicals. Less

本研究的目的是建立牙科树脂中双酚A的微量分析方法，并确定双酚A是否是由未聚合单体通过分解反应等产生的。此外，还选择了评估聚合过程中双酚A含量可能减少的情况。1。双酚A量的微量分析双酚A量的微量分析使用石英容器，以尽可能有效地消除碱金属离子的污染。对于甲醇-水混合物的流动相，甲醇/水=80/20最合适，对于乙腈-水混合物的流动相，乙腈/水=60/40最合适。根据不同试样的性质，建立了优化设计的显微分析方法。 2．双酚A相关化合物因分解而释放出双酚A。在酸性或碱性环境下，Bis-DMA很容易分解为双酚A。另一方面，虽然 Bis-GMA 分解成 BHP（水解过程中形成的中间体），但没有观察到 BHP 形成双酚 A。综上所述，由Bis-GMA生产双酚A的可能性很小，因为BHP中间体在水解过程中非常稳定。 3．双酚A与树脂固化过程中形成的自由基的相互作用当使用2,2'-偶氮二(异丁腈)作为引发剂时，诱导期随着双酚A添加量的增加而增加。这表明双酚A是典型的阻聚剂。在过氧化苯甲酰（BPO）引发的聚合反应中，双酚A比对苯二酚产生了更长的诱导期，这表明在BPO存在下，双酚A比后者更有效地作为抑制剂。据认为，牙科树脂在固化开始时不再存在双酚A，因为树脂中作为杂质含有的双酚A通过与引发剂自由基的反应而被消耗。较少的

项目成果

藤沢盛一郎: "BPO(AIBN)-MMA重合システムにおける誘導期間と初期重合速度に及ぼすビタミンAおよびβ-カロチンの影響"歯科材料・器械. 17(6). 321-325 (1998)

Seiichiro Fujisawa：“维生素 A 和 β-胡萝卜素对 BPO(AIBN)-MMA 聚合体系中诱导期和初始聚合速率的影响”牙科材料和仪器 17(6) (1998)。

Yoshinori Kadoma et al.: "Acid and base-catalyzed hydrolysis of bisphenol A related compounds"Dent. Mater. J.. 19(2) (in press). (2000)

Yoshinori Kadoma 等：“双酚 A 相关化合物的酸和碱催化水解”Dent。

Seiichiro Fujisawa: "DSC and NMR spectroscopic studies of the interaction between camphorated phenol and phospholipid liposomes"Dent. Mater. J.. 17(4). 314-320 (1998)

Seiichiro Fujisawa：“樟脑酚与磷脂脂质体之间相互作用的 DSC 和 NMR 光谱研究”Dent。

Yoshinori Kadoma: "Acid and base-catalyzed hydrolysis of bisphenol A related compounds"Dent.Mater.J.. 19(2)(発表予定). (2000)

Yoshinori Kadoma：“双酚A相关化合物的酸和碱催化水解”Dent.Mater.J.. 19(2)（待出版）。

Yoshinori Kadoma: "Acid and base-catalyzed hydrolysis of bisphenol A related compounds"Dent. Mater. J.. 19(2)(発表予定). (2000)

Yoshinori Kadoma：“双酚 A 相关化合物的酸和碱催化水解”，Dent. 19(2)（待出版）。