Biomaterial nano-particles development by low voltage electrolysis with polarity inversion

通过极性反转低压电解开发生物材料纳米颗粒

• 批准号: 18592116
• 负责人: OKAWA Seigo
• 金额: $ 1.08万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592116/
• 关键词: Biomaterial; Nano-material; Calcium phosphate; Valve metal; Anodic oxidation; ナノ材料; チタン

In order to make a calcium phosphate compound with nano-size on valve metals such as Ta, Nb, and Zr, electrochemical deposition of calcium phosphate on different metals was performed by anodic oxidation with alternate polarity inversion at an applied 20 VDC. A saturated hydroxyapatite (HAP)-phosphoric acid solution (pH 3) was used as the electrolyte. FTIR, XRD, and XPS were employed to investigate the detailed characteristics of the deposition. HAP was precipitated on Ta; HAP including brushite and monetite on Nb; and HAP and monetite on Zr. The Ca/P atomic ratios were 1.3-1.5 by XPS, and HPO42- bands were detected on Ta by FTIR. Therefore, the HAP precipitated on Ta was a Ca-deficient HAP. In addition, the XPS spectra of the specimens showed that phosphate ions were incorporated into the anodic oxide film. Deposits with nano-grain size were observed by AFM, and their morphologies depended on the surface characteristics of the valve metal. The results confirmed that anodic oxidation with polarity inversion was effective in accelerating the deposition of calcium phosphate with nano-grain size on valve metals. Such valve metals having this characteristic should be potentially bioactive.

为了在Ta、Nb、Zr等阀门金属表面制备纳米级的磷酸钙化合物，在20V直流电压下，采用交替变极性的阳极氧化方法在不同的金属表面进行了磷酸钙的电化学沉积。以饱和羟基磷灰石(HAP)-磷酸溶液(pH=3)为电解液。用红外光谱、X射线衍射仪和X射线光电子能谱对沉积过程进行了详细的表征。HAP在Ta上析出，HAP在Nb上析出，HAP在Nb上析出，HAP在Zr上析出。XPS分析表明钙磷原子比为1.3-1.5，FTIR检测到Ta表面有HPO42-谱带。因此，沉淀在Ta上的HAP是一种缺钙的HAP。此外，样品的XPS谱表明，磷酸根离子已进入阳极氧化膜。利用原子力显微镜观察到了纳米颗粒的沉积，其形貌取决于阀门金属的表面特征。结果表明，极性反转阳极氧化能有效地促进阀门金属表面纳米级磷酸钙的沉积。这种具有这种特性的阀门金属应该具有潜在的生物活性。

项目成果

CaとPを含む溶液中でチタンの陽極酸化により析出したナノ粒子のXPS分析

在含 Ca 和 P 的溶液中阳极氧化钛沉积的纳米颗粒的 XPS 分析

• 发表时间: 2006
• 期刊: 歯科材料・器械 25・5
• 作者: 大川成剛;金谷 貢;他3名
• 通讯作者: 他3名

Calcium phosphate nanoparticles deposited by anodic oxidation of titanium

钛阳极氧化沉积的磷酸钙纳米粒子

• 发表时间: 2006
• 期刊: CD-ROM OF ABSTRACTS Journal of Dental Research 85・Special Issue B
• 作者: S.Okawa;M.Kanatani;et al.
• 通讯作者: et al.

Characterization of Calcium Phosphate Compound Deposited on Valve Metals with Anodic Oxidation Process

阳极氧化工艺沉积在阀金属上的磷酸钙化合物的表征

• 发表时间: 2007
• 作者: Okawa S;Homma K;Nakano S;Kanatani M;Watanabe K.
• 通讯作者: Watanabe K.