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Effects of systemic factors on root resorption duiing orthodontic tooth movement

全身因素对正畸牙移动牙根吸收的影响

基本信息

批准号：
18592238
负责人：
IOI Hideki
金额：
$ 2.37万
依托单位：
Kyushu University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18592238/
关键词：
dentistry orthodontics root resorption

项目摘要

【Clinical epidemiological study】Effects of systemic factors on root resorption duiing orthodontic tooth movement in humanThe objective of this study was to determine whether there is an association between excessive root resorption and immune system factors. The questionnaire sought information on medical history included local or systemic diseases, details on medication type and use, and the presence of allergies and asthma. In this study, we determined the presence of allergies and asthma by the diagnosis of medical doctors. Moreover, we conducted the study to determine whether there is an association between TMJ osteoarthritis/osteoarthrosis (OA) and immune system factors. The records of 41 subjects (7 males, age 22.0 ± 3.8 years; 34 females, age 24.8 ± 6.3 years)and 41 pair-matched controls (7 males, age 22.1 ± 2.3 years; 34 females, age 24.8 ± 6.4 years) based on age and gender, were reviewed. Information on medical history included local or systemic diseases, details on medicatio … More n type and use, and the presence of allergies and asthma. Dental history questions referred to details regarding past oral injuries. The validity of our hypothesis, defining allergies and asthma as risk factors in OA, was tested by using the logistic regression analysis. The incidence of allergy was significantly higher in the TMJ OA (p=.008) , with a mean odds ratio of 4.125 and 95% confidence interval of 1.446-11.769. These results suggest that allergy may be a risk factor in association with TMJ OA in this Japanese sample.【Animal experiment study】Effect of systemic inflammation factors on root resorption during orthodontic tooth movement in ratsThe primary purpose of this study was to determine whether there is an association between excessive root resorption and the systemic factors in rats with adjuvant-induced inflammation. The maxillary first molar was moved using a removable titanium-nickel alloy closed coil spring for 7days. On day 7 of tooth movement, the rats were sacrificed and the maxillae were immediately removed, fixed, and decalcified in 10 % EDTA solution. The tissues were then snap-frozen in liquid nitrogen. The histochemical staining for TRAP was carried out to identify osteoclasts and odontoclasts for active bone and root resorption. The roots of the maxillary first molars from adjuvant rats had significantly greater TRAP positive scores than those of the control group. Less

【临床流行病学研究】全身因素对正畸牙齿移动引起的牙根吸收的影响本研究的目的是确定过度的牙根吸收与免疫系统因素之间是否存在关联。调查问卷寻求有关病史的信息，包括局部或全身疾病、药物类型和使用的详细信息以及是否存在过敏和哮喘。在这项研究中，我们通过医生的诊断来确定是否存在过敏和哮喘。此外，我们进行了这项研究，以确定颞下颌关节骨关节炎/骨关节病 (OA) 与免疫系统因素之间是否存在关联。根据年龄和性别，对 41 名受试者（7 名男性，年龄 22.0 ± 3.8 岁；34 名女性，年龄 24.8 ± 6.3 岁）和 41 名配对对照（7 名男性，年龄 22.1 ± 2.3 岁；34 名女性，年龄 24.8 ± 6.4 岁）的记录进行了审查。病史信息包括局部或全身疾病、药物类型和用途的详细信息，以及是否存在过敏和哮喘。牙科病史问题涉及有关过去口腔损伤的详细信息。我们的假设（将过敏和哮喘定义为 OA 的危险因素）的有效性通过逻辑回归分析进行了检验。 TMJ OA 的过敏发生率显着较高 (p=.008)，平均比值比为 4.125，95% 置信区间为 1.446-11.769。这些结果表明，过敏可能是该日本样本中与TMJ OA相关的危险因素。【动物实验研究】全身炎症因素对大鼠正畸牙齿移动过程中牙根吸收的影响本研究的主要目的是确定佐剂引起的炎症大鼠过度牙根吸收与全身因素之间是否存在关联。使用可拆卸钛镍合金封闭螺旋弹簧移动上颌第一磨牙7天。牙齿移动第7天，处死大鼠，立即取出上颌骨，固定，并在10% EDTA溶液中脱钙。然后将组织在液氮中速冻。对TRAP进行组织化学染色，以鉴定破骨细胞和破牙细胞对骨和牙根吸收的活性。辅助组大鼠上颌第一磨牙根部的 TRAP 阳性评分显着高于对照组。较少的