Effects of systemic factors on root resorption duiing orthodontic tooth movement

【临床流行病学研究】人体正畸牙齿移动过程中系统因素对牙根吸收的影响本研究旨在探讨过度牙根吸收与免疫系统因素之间是否存在关联。调查问卷寻求的病史信息包括局部或全身性疾病，药物类型和使用的详细信息，以及过敏和哮喘的存在。在这项研究中，我们通过医生的诊断来确定过敏和哮喘的存在。此外，我们还进行了研究，以确定TMJ骨关节炎/骨关节病（OA）与免疫系统因素之间是否存在关联。回顾性分析41例（男性7例，年龄22.0±3.8岁；女性34例，年龄24.8±6.3岁）和41例按年龄和性别配对的对照组（男性7例，年龄22.1±2.3岁；女性34例，年龄24.8±6.4岁）。病史信息包括局部或全身性疾病，药物细节…更多的类型和使用，以及过敏和哮喘的存在。牙齿病史问题涉及过去口腔损伤的细节。我们将过敏和哮喘定义为OA的危险因素，并通过logistic回归分析来检验假设的有效性。TMJ OA过敏发生率显著高于TMJ OA (p= 0.008)，平均优势比为4.125,95%可信区间为1.446 ~ 11.769。这些结果表明，过敏可能是日本样本中与颞下颌关节关节炎相关的一个危险因素。【动物实验研究】全身性炎症因子对正畸大鼠牙齿运动过程中牙根吸收的影响本研究的主要目的是探讨佐剂诱导的炎症大鼠牙根过度吸收与全身性炎症因子之间是否存在关联。上颌第一磨牙使用可拆卸钛镍合金封闭线圈弹簧移动7天。拔牙第7天处死大鼠，即刻拔牙固定，用10% EDTA溶液脱钙。然后将组织快速冷冻在液氮中。利用TRAP的组织化学染色来鉴定破骨细胞和破牙细胞对骨和根的活性吸收。佐剂大鼠上颌第一磨牙牙根TRAP阳性评分明显高于对照组。少

【Clinical epidemiological study】Effects of systemic factors on root resorption duiing orthodontic tooth movement in humanThe objective of this study was to determine whether there is an association between excessive root resorption and immune system factors. The questionnaire sought information on medical history included local or systemic diseases, details on medication type and use, and the presence of allergies and asthma. In this study, we determined the presence of allergies and asthma by the diagnosis of medical doctors. Moreover, we conducted the study to determine whether there is an association between TMJ osteoarthritis/osteoarthrosis (OA) and immune system factors. The records of 41 subjects (7 males, age 22.0 ± 3.8 years; 34 females, age 24.8 ± 6.3 years)and 41 pair-matched controls (7 males, age 22.1 ± 2.3 years; 34 females, age 24.8 ± 6.4 years) based on age and gender, were reviewed. Information on medical history included local or systemic diseases, details on medicatio … More n type and use, and the presence of allergies and asthma. Dental history questions referred to details regarding past oral injuries. The validity of our hypothesis, defining allergies and asthma as risk factors in OA, was tested by using the logistic regression analysis. The incidence of allergy was significantly higher in the TMJ OA (p=.008) , with a mean odds ratio of 4.125 and 95% confidence interval of 1.446-11.769. These results suggest that allergy may be a risk factor in association with TMJ OA in this Japanese sample.【Animal experiment study】Effect of systemic inflammation factors on root resorption during orthodontic tooth movement in ratsThe primary purpose of this study was to determine whether there is an association between excessive root resorption and the systemic factors in rats with adjuvant-induced inflammation. The maxillary first molar was moved using a removable titanium-nickel alloy closed coil spring for 7days. On day 7 of tooth movement, the rats were sacrificed and the maxillae were immediately removed, fixed, and decalcified in 10 % EDTA solution. The tissues were then snap-frozen in liquid nitrogen. The histochemical staining for TRAP was carried out to identify osteoclasts and odontoclasts for active bone and root resorption. The roots of the maxillary first molars from adjuvant rats had significantly greater TRAP positive scores than those of the control group. Less