Effects of systemic factors on root resorption duiing orthodontic tooth movement

[临床流行病学研究]正畸牙移动过程中全身因素对牙根吸收的影响本研究旨在探讨免疫系统因素与牙根吸收过度之间的关系。调查问卷收集的病史信息包括局部或全身性疾病、药物类型和使用的详细信息以及过敏和哮喘的存在。在这项研究中，我们通过医生的诊断来确定过敏和哮喘的存在。此外，我们进行了这项研究，以确定是否有颞下颌关节骨关节炎/骨关节病（OA）和免疫系统因素之间的关联。根据年龄和性别，审查了41例受试者（7例男性，年龄22.0 ± 3.8岁; 34例女性，年龄24.8 ± 6.3岁）和41例配对对照（7例男性，年龄22.1 ± 2.3岁; 34例女性，年龄24.8 ± 6.4岁）的记录。病史信息包括局部或全身性疾病、用药详情、 关于我们 n类型和使用，以及过敏和哮喘的存在。牙科史问题涉及有关过去口腔损伤的详细信息。我们的假设的有效性，定义过敏和哮喘的风险因素在OA，进行了测试，通过使用逻辑回归分析。TMJ OA患者的过敏发生率显著较高（p= 0.008），平均比值比为4.125，95%置信区间为1.446-11.769。这些结果表明，过敏可能是一个危险因素与TMJ OA在这个日本样本。【动物实验研究】全身炎症因素对大鼠正畸牙移动过程中牙根吸收的影响本研究的主要目的是探讨正畸炎症大鼠牙根吸收过度与全身因素是否存在相关性。上颌第一磨牙用可摘式钛镍合金闭合螺旋弹簧移动7 d。在牙齿移动的第7天，处死大鼠，立即取出上颌骨，固定，并在10%EDTA溶液中脱钙。然后将组织在液氮中快速冷冻。用TRAP组织化学染色鉴定破骨细胞和破牙细胞对活性骨和牙根吸收的作用。佐剂组大鼠上颌第一磨牙牙根TRAP阳性评分明显高于对照组。少

【Clinical epidemiological study】Effects of systemic factors on root resorption duiing orthodontic tooth movement in humanThe objective of this study was to determine whether there is an association between excessive root resorption and immune system factors. The questionnaire sought information on medical history included local or systemic diseases, details on medication type and use, and the presence of allergies and asthma. In this study, we determined the presence of allergies and asthma by the diagnosis of medical doctors. Moreover, we conducted the study to determine whether there is an association between TMJ osteoarthritis/osteoarthrosis (OA) and immune system factors. The records of 41 subjects (7 males, age 22.0 ± 3.8 years; 34 females, age 24.8 ± 6.3 years)and 41 pair-matched controls (7 males, age 22.1 ± 2.3 years; 34 females, age 24.8 ± 6.4 years) based on age and gender, were reviewed. Information on medical history included local or systemic diseases, details on medicatio … More n type and use, and the presence of allergies and asthma. Dental history questions referred to details regarding past oral injuries. The validity of our hypothesis, defining allergies and asthma as risk factors in OA, was tested by using the logistic regression analysis. The incidence of allergy was significantly higher in the TMJ OA (p=.008) , with a mean odds ratio of 4.125 and 95% confidence interval of 1.446-11.769. These results suggest that allergy may be a risk factor in association with TMJ OA in this Japanese sample.【Animal experiment study】Effect of systemic inflammation factors on root resorption during orthodontic tooth movement in ratsThe primary purpose of this study was to determine whether there is an association between excessive root resorption and the systemic factors in rats with adjuvant-induced inflammation. The maxillary first molar was moved using a removable titanium-nickel alloy closed coil spring for 7days. On day 7 of tooth movement, the rats were sacrificed and the maxillae were immediately removed, fixed, and decalcified in 10 % EDTA solution. The tissues were then snap-frozen in liquid nitrogen. The histochemical staining for TRAP was carried out to identify osteoclasts and odontoclasts for active bone and root resorption. The roots of the maxillary first molars from adjuvant rats had significantly greater TRAP positive scores than those of the control group. Less