Elucidation and suppression of the orthodontically induced root resorption in patients with allergic condition

在本研究中，我们调查了过敏对牙齿移动、骨和牙根吸收的影响。正畸力作用24小时后，卵清蛋白（OVA）致敏大鼠牙根吸收增加。与未致敏大鼠相比，OVA致敏大鼠TNF-α、IL-1β、IL-6等细胞因子的表达水平升高。此外，LT表达和5-脂氧合酶的mRNA表达水平也上调。阿司匹林抑制牙根吸收和细胞因子的产生。

In the present study, we investigated the effects of allergies on tooth movement and bone and tooth root resorption. Tooth root resorption were increased in ovalbumin(OVA)-sensitized rats subjected to orthodontic force for 24 hours. The expression levels of cytokines such as TNF-α, IL-1β, IL-6 were increased in OVA-sensitized rats, compared with non-sensitized rats. Furthermore, LT expression and the mRNA expression levels of 5-lipoxygenase were also upregulated. Aspirin suppressed tooth root resorption and the cytokines productions.