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Development of new adhesive systems based on the characteristics of primary tooth dentin

根据乳牙牙本质特性开发新型粘接体系

基本信息

批准号：
18592240
负责人：
HOSOYA Yumiko
金额：
$ 2.43万
依托单位：
Nagasaki University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

项目摘要

Primary dentin has significantly lower physical properties than permanent tooth dentin, and more susceptible to chemicals. The purpose of this study was to develop a new adhesive system with mild acid-etching ability, adequate penetration into the caries-affected dentin and simple and easy to clinical use.Materials, Methods and Results :Sun-Medicals 4-META one-step self-etch adhesives AQ Bond Plus (AQBP)or Hybrid Bond (HB, new product)was applied on the sound or caries-affected primary tooth dentin.#Test 1 : resin-dentin interfaces were measured with a nano-indentation tester and the hardness (H)and Young's modulus(Y)were calculated.#Test 2 : Ultrastructures of resin-dentin interfaces were observed with FE-SEM, SEM and TEM.(1)Only in the carious-HB group, the H and Y of the interfacial dentin were not significantly lower than those obtained from 10-70 μm beneath the interface.(2)Both in the sound-AQBP and sound-HB groups, the H of the interfacial dentin was significantly lower than those obtained from 10-70 μm beneath the interface.(3)Compared with sound primary tooth dentin, the H and Y values of adhesive layer of AQBP and HB were about 1/2 and 1/3, respectively.(4)The hybrid layer of both adhesives was about 1 μm thick.(5)In the sound dentin, silver nanoleakage was observed along the interface both in the AQBP and HB groups.(6)In the carious teeth, silver nanoleakage was not seen in the hybrid layer and many of the dentinal tubules were filled with mineral deposits that prevented silver nanoleakage. However, silver deposits were seen in the underlying porous caries-affected dentin.In both adhesive groups, silver nanoleakage was observed in these resin-dentin interfaces and porous caries-affected dentin. Those results might deteriorate effect of clinical prognosis of resin restorations. Further improvements of one-step self-etch adhesives are required to obtain stable adhesion

初级牙本质的物理特性明显低于恒牙牙本质，并且更容易受到化学物质的影响。本研究的目的是开发一种具有温和酸蚀能力、能充分渗透到受龋齿影响的牙本质、且简单且易于临床使用的新型粘合剂体系。材料、方法和结果：将Sun-Medicals 4-META一步式自酸蚀粘合剂AQ Bond Plus（AQBP）或Hybrid Bond（HB，新产品）应用于健全或受龋齿影响的乳牙牙本质。#测试1：用纳米压痕仪测量树脂-牙本质界面，并计算硬度（H）和杨氏模量（Y）。#测试2：用FE-SEM、SEM和TEM观察树脂-牙本质界面的超微结构。（1）仅在龋坏-HB组中，界面牙本质的H和Y不明显低于牙本质下方10-70μm处的结果。 (2)无论是sound-AQBP组还是sound-HB组,界面牙本质的H均显着低于界面下10~70μm处的牙本质。(3)与完好乳牙牙本质相比,AQBP和HB的粘接层H和Y值分别约为1/2和1/3。(4)两种粘接剂的混合层约为1μm (5)在健全的牙本质中，AQBP组和HB组均沿界面观察到银纳米渗漏。(6)在龋齿中，混合层中未观察到银纳米渗漏，并且许多牙本质小管充满了阻止银纳米渗漏的矿物质沉积物。然而，在下面的多孔龋齿影响的牙本质中发现了银沉积。在两个粘合剂组中，在这些树脂-牙本质界面和多孔龋齿影响的牙本质中观察到银纳米渗漏。这些结果可能会恶化树脂修复体的临床预后效果。需要进一步改进一步式自蚀刻粘合剂以获得稳定的粘合力