The Structure Function and Biology of Serpins

丝氨酸蛋白酶抑制剂的结构功能和生物学

• 批准号: DP0342866
• 负责人: Prof Stephen Bottomley
• 金额: $ 31.41万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0342866
• 关键词: Structure; Function; Biology; Serpins

The serpin family of proteins control protease activity, in a variety of biological systems, via a dramatic conformational change. We are 4 leaders in the serpin reseacrh field using an integrated approach of biochemistry, biophysics, molecular biology, cell biology, structural biology and bioinformatics to analyse every facet of serpin structure, function and biology. We will apply and develop novel technologies that will determine how these conformational changes are achieved and how they are controlled. Our increased understanding of this inhibitor - enzyme interaction will have implications to other proteins which undergo conformational change and biotechnology.

丝氨酸蛋白酶抑制剂家族的蛋白质控制蛋白酶的活性，在各种生物系统中，通过一个显着的构象变化。我们是丝氨酸蛋白酶抑制剂研究领域的4位领导者，采用生物化学，生物物理学，分子生物学，细胞生物学，结构生物学和生物信息学的综合方法来分析丝氨酸蛋白酶抑制剂结构，功能和生物学的各个方面。我们将应用和开发新的技术，将确定如何实现这些构象变化，以及如何控制它们。我们对这种抑制剂-酶相互作用的进一步了解将对其他经历构象变化的蛋白质和生物技术产生影响。