Analysing the detrimental effects of polyglutamine expansion

分析聚谷氨酰胺扩增的有害影响

• 批准号: DP1095102
• 负责人: Prof Stephen Bottomley
• 金额: $ 20.89万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP1095102
• 关键词: Analysing; detrimental; effects; polyglutamine; expansion

The proposed research program, will provide significant fundamental insight into the processes that control protein aggregation and its link with disease. Investigating processes central to protein aggregation is important as it will deepen our understanding of how proteins inappropriately change shape and our understanding of disease processes. Such knowledge will increase Australia's international research standing, as well as having the potential to generate novel therapies, that prevent neurodegeneration.

拟议的研究计划将为控制蛋白质聚集及其与疾病的联系的过程提供重要的基础性见解。研究蛋白质聚集的核心过程很重要，因为它将加深我们对蛋白质如何不适当地改变形状的理解，以及我们对疾病过程的理解。这些知识将提高澳大利亚在国际研究中的地位，并有可能产生防止神经退化的新疗法。