Development of statistical genetic models and hierarchical Bayes procedures to predict emergence and dynamics of resistant alleles

开发统计遗传模型和分层贝叶斯程序来预测耐药等位基因的出现和动态

• 批准号: 19300094
• 负责人: KISHINO Hirohisa
• 金额: $ 11.73万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300094/
• 关键词: MCMC; 立体構造データベースと尤度; 配列進化と構造進化; 分子系統樹; ベイズ階層モデル; 統計遣伝学; 適応度ランドスケープ; ゲノム組換え; 統計遺伝学; 立体構造データベース; 銃計遣伝学

Setting a virus as a main target of the research, we developed new statistical models and procedures to estimate its genetic diversity and to predict the emergence of resistant alleles. Our hierarchical Bayes model detects inconsistency of phylogenetic relation between the segments of the genomes and estimates the recombination history. By our knowledge-based measure of the binding ability of a protein complex, it became possible to predict the change in the values of the coefficients that specify a population dynamic model. As a result, it became possible to predict the types and timing of new resistant alleles that are likely to be fixed among host population.

以病毒为主要研究对象，我们开发了新的统计模型和程序来估计其遗传多样性并预测抗性等位基因的出现。我们的层次贝叶斯模型检测基因组片段之间系统发育关系的不一致性，并估计重组历史。通过对蛋白质复合物结合能力的基于知识的测量，可以预测指定种群动态模型的系数值的变化。因此，有可能预测宿主群体中可能固定的新抗性等位基因的类型和时间。

项目成果

Structural Considerations in the Fitness Landscape of a Virus

• DOI: 10.1093/molbev/msq056
• 发表时间: 2010-08-01
• 期刊: MOLECULAR BIOLOGY AND EVOLUTION
• 影响因子: 10.7
• 作者: Watabe, Teruaki;Kishino, Hirohisa
• 通讯作者: Kishino, Hirohisa

Distribution of distances between topologies and its effect on detection of phylogenetic recombination.

拓扑之间距离的分布及其对系统发育重组检测的影响。

• 发表时间: 2010
• 期刊: Annals of the Institute of Statistical Mathematics. 62
• 作者: de Oliveira Martins;L.;Kishino;H.
• 通讯作者: H.

Major contribution of dominant inheritance to autism spectrum disorder(ASD)in populationbased families.

显性遗传对人口家庭中自闭症谱系障碍（ASD）的主要贡献。

• 发表时间: 2009
• 期刊: Journal of Human Genetics. 54
• 作者: Nishiyama;T.;Notohara;M.;Sumi;S.;Takami;S.;Kishino;H.
• 通讯作者: H.

Statistical comparison of nucleotide-, amino acid-, and codon-substitution models

核苷酸、氨基酸和密码子取代模型的统计比较

• 发表时间: 2008
• 作者: R. Shibata;Y. Tanizawa;Tae-KUn Seo and Hirohisa Kishir.
• 通讯作者: Tae-KUn Seo and Hirohisa Kishir.

Adaptive Threonine Increase in Transmembrane Regions of Mitochondrial Proteins in Higher Primates

• DOI: 10.1371/journal.pone.0003343
• 发表时间: 2008-10-06
• 期刊: PLOS ONE
• 影响因子: 3.7
• 作者: Kitazoe, Yasuhiro;Kishino, Hirohisa;Tanaka, Masashi
• 通讯作者: Tanaka, Masashi