Development of consomic mouse model for metabolic syndrome

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The development of metabolic syndrome is found in NZO/HILtJ mice, but not in C3H/HeJ mice. We identified quantitative trait loci associated with obesity, abnormal glucose metabolism and hypertension. To develop the animal model for understanding the molecular mechanism of metabolic syndrome, we successfully produced three consomic mouse strains, NZO/HILtJ-Chr 7^<C3H/HeJ,>, NZO/HILtJ-Chr 12^<C3H/HeJ> and NZO/HILtJ-Chr 17^<C3H/HeJ>. There were no significant differences in obesity, glucose metabolism and blood pressure between the consomic mice and NZO/HILtJ mice. These results demonstrate that a single major gene associated with metabolic syndrome was not located on the chromosome 7, 12 and 17 of NZO/HILtJ mice. Furthermore, we found Fgf5-deficient natural mutant mice from ICR mouse colony supporting the breeding of NZO/HILtJ mice. The Fgf5-decifient mice might be useful animal model for the basic research of hypertension and metabolic syndrome, because there is strong significant association between hypertension and Fgf5 polymorphism in human.