Roles of adult neurogenesis in mood and emotion

成人神经发生在情绪和情绪中的作用

• 批准号: 19300136
• 负责人: HITOSHI Seiji
• 金额: $ 12.06万
• 依托单位: National Institute for Physiological Sciences
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19300136/
• 关键词: 神経機能の可塑性; 成体脳神経細胞新生; 神経幹細胞; テトラサイクリン誘導システム; 神経細胞新生; 情動; ストレス; Notchシグナル; 齧歯類; 霊長類

In this study, we aimed to clarify a possible causative link between NSCs and neurogenesis in the adult brain and mood/emotion and to explore a possibility to alter the mood or other brain functions by modification of the number of NSCs. First, we demonstrated that chronic stress decreases the number of NSCs in the adult brain and that this reduction can be restored by antidepressant treatment. Second, we found that mood stabilizing drugs, which are used to treat patients with bipolar disorder, enhance the self-renewal capability of mouse NSCs and that this pharmacological effects are mediated by the activation of Notch signaling in the NSC. Third, we developed a transgenic mouse system, in which numbers of NSCs can be manipulated by administration of doxycyclin. Our results could contribute to the understanding of pathogenesis of modd affective disorders and to the development of new therapeutic strategy for neuro-psychiatric diseases.

在这项研究中，我们的目的是阐明神经干细胞与成人大脑神经发生和情绪/情绪之间可能存在的因果关系，并探索通过改变神经干细胞数量来改变情绪或其他大脑功能的可能性。首先，我们证明慢性压力会减少成人大脑中神经干细胞的数量，并且这种减少可以通过抗抑郁治疗来恢复。其次，我们发现用于治疗双相情感障碍患者的情绪稳定药物可以增强小鼠 NSC 的自我更新能力，并且这种药理作用是通过激活 NSC 中的 Notch 信号传导来介导的。第三，我们开发了一种转基因小鼠系统，其中可以通过施用强力霉素来控制 NSC 的数量。我们的结果可能有助于了解现代情感障碍的发病机制，并有助于开发神经精神疾病的新治疗策略。

项目成果

Neural stem cells in the adult brain: implications for the pathogenesis of mood affective disorders.

成人大脑中的神经干细胞：对情绪情感障碍发病机制的影响。

• 发表时间: 2009
• 作者: Umezawa M.;Higuchi K.;Mori M.;Matsushita T;Hosokawa M.;Hitoshi S.
• 通讯作者: Hitoshi S.

Time-dependent central compensatory mechanisms of finger dexterity after spinal cord injury

• DOI: 10.1126/science.1147243
• 发表时间: 2007-11-16
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Nishimura, Yukio;Onoe, Hirotaka;Isa, Tadashi
• 通讯作者: Isa, Tadashi

Regulation of glial development by cystatin C

• DOI: 10.1111/j.1471-4159.2006.04169.x
• 发表时间: 2007-01-01
• 期刊: JOURNAL OF NEUROCHEMISTRY
• 影响因子: 4.7
• 作者: Hasegawa, Akiko;Naruse, Masae;Ikenaka, Kazuhiro
• 通讯作者: Ikenaka, Kazuhiro

A subcortical oscillatory network contributes to recovery of hand dexterity after spinal cord injury.

• DOI: 10.1093/brain/awn338
• 发表时间: 2009-03
• 期刊: Brain : a journal of neurology
• 作者: Nishimura Y;Morichika Y;Isa T
• 通讯作者: Isa T

Functional central nervous system myelin repair in an adult mouse model of demyelination caused by proteolipid protein overexpression.

蛋白脂质蛋白过度表达引起的脱髓鞘成年小鼠模型中的功能性中枢神经系统髓鞘修复。

• DOI: 10.1002/jnr.22334
• 发表时间: 2010
• 期刊: Journal of neuroscience research
• 影响因子: 4.2
• 作者: Espinosa-Jeffrey,A;Hitoshi,S;Zhao,P;Awosika,O;Agbo,C;Olaniyan,E;Garcia,J;Valera,R;Thomassian,A;Chang-Wei,R;Yamaguchi,M;deVellis,J;Ikenaka,K
• 通讯作者: Ikenaka,K