Evaluation of Angiogenesis by High Resolution Three-dimensional Ultrasound Molecular Imaging

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High resolution three-dimensional ultrasound molecular imaging was developed for evaluation of angiogenesis in small animals such as mice. The following were achieved ; 1. Three-dimensional ultrasound imaging system with the frequency range up to 150 MHz and the spatial resolution of 10 micron, 2. Image analysis algorithm for classification of vessels and surrounding tissues by correlation of RF signals in the consecutive frames, 3. Portable scanner for easy and repetitive use, 4. Molecular imaging of angiogenesis with labeled nano-bubble.