Is an increase in GLUT4 mRNA in response to exercise training mediated by MEF2?

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To examine whether MEF2 was involved in an increase in GLUT4 mRNA by exercise training, MEF2 overexpressed transgenic mice in skeletal muscles were produced. MEF2 overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. Transcription co-activators, PGC-1α-b and PGC-1α-c, are increased by exercise training and activate MEF2. However, PGC-1α-b or PGC-1α-c overexpressed mice did not increase GLUT4 mRNA in skeletal muscles. These data suggested that MEF2 was not involved in an increase in GLUT4 mRNA by exercise training.