Development of Innovative Radical Reactions by Means of Species Hybridization

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This research aimed at development of new radical reactions in which both radical species and non-radical species play a key role. Borohydride reagents proved to function as efficient radical mediators. As a notable example, hydroxymethylation of iodoalkanes proceeded using atmospheric pressure of CO and tertrabutylammonium borohydride. Under photo-irradiation conditions, in the presence of Pd complexes, three component coupling reaction of iodoalkanes, CO and terminal alkynes proceeded efficiently to give good yields of acetylenic ketones. Lactol forming reaction was also attained via ionic trapping of acyl radicals by an internal hydroxy group.