Roles of tyrosine kinases during evolution of multicellular animals
Roles of tyrosine kinases during evolution of multicellular animals
批准号:
19370053
负责人:
OKADA Masato
金额:
$11.81万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
蛋白質のチロシン残基特異的リン酸化酵素(チロシンキナーゼ)は動物特有の酵素である。本研究では、多細胞動物の成立におけるチロシンキナーゼの意義を明らかするために、動物の祖先とされる単細胞原生生物(立襟鞭毛虫)、原始的な多細胞動物(海綿)、および、特殊に進化した線形動物(線虫)をモデルとして用いた解析を行い、チロシンキナーゼおよびその下流因子の活性制御系が動物の多細胞化の過程で発達あるいは特殊化してきたことを明らかにした。
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Functional transition of proto-oncogenes during evolution of multicellularity in animals
动物多细胞进化过程中原癌基因的功能转变
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[小根山千歳, 疋田智也, 塩谷健悟, 岡田雅人, 黒岩美帆, 辰巳真有美, 小根山千歳, 疋田智也, 高橋佑介, 鈴木慶, 井上健, 渡利彰浩]
通讯作者:
渡利彰浩
DOI:
10.1111/j.1365-2443.2007.01145.x
发表时间:
2008-01-01
期刊:
GENES TO CELLS
影响因子:
2.1
作者:
[Oneyama, Chitose, Hikita, Tomoya, Okada, Masato]
通讯作者:
Okada, Masato
Non-receptor tyrosine kinase CSK-1 controls pharyngeal muscle organization in Caenorhabditis elegans
非受体酪氨酸激酶 CSK-1 控制秀丽隐杆线虫咽部肌肉组织
DOI:
--
发表时间:
2009
期刊:
Genes to Cells (印刷中)
影响因子:
--
作者:
[Nishimoto, S., Nishida, E., Nozomu Takata]
通讯作者:
Nozomu Takata
線虫C. elegansにおけるmechanosensory neuronの極性決定に関わる遺伝子群のスクリーニング
秀丽隐杆线虫机械感觉神经元极性决定相关基因的筛选
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[東恒仁, 和田郁夫, 増田瞳]
通讯作者:
増田瞳
Ablation of Csk in neural crest lineages causes corneal anomaly by deregulating collagen fibril organization and cell motility
神经嵴谱系中 Csk 的消融通过解除胶原纤维组织和细胞运动的调节而导致角膜异常
DOI:
--
发表时间:
2008
期刊:
Developmental Biology (in press)
影响因子:
--
作者:
[Atsuko, Takatsuka]
通讯作者:
Takatsuka
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海外基金