The extracellular microenvironment and its signal regulations operated by proteoglycans
The extracellular microenvironment and its signal regulations operated by proteoglycans
批准号:
19390116
负责人:
WATANABE Hideto
金额:
$11.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
To understand in vivo function of versican, a large proteoglycan in the extracellular matrix, we generated analyzed its conditional knockout mice. Through their analyses, we found that versican regulates BMP- and TGFβ-mediated signaling and plays crucial roles in several steps of cardiac development, chondrogenesis, and joint morphogenesis.
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生体内におけるバーシカン/PG-Mの機能
多功能蛋白聚糖/PG-M的体内功能
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[Hirai M, et. al., Hirai M.et al., 渡辺 秀人, Lotery A.J.et al., Hideto Watanabe, 中邨智之, 渡辺 秀人]
通讯作者:
渡辺 秀人
DOI:
10.1074/jbc.m806927200
发表时间:
2009-03
期刊:
Journal of Biological Chemistry
影响因子:
4.8
作者:
[Keittisak Suwan;Kanyamas Choocheep;S. Hatano;P. Kongtawelert;K. Kimata;H. Watanabe]
通讯作者:
Keittisak Suwan;Kanyamas Choocheep;S. Hatano;P. Kongtawelert;K. Kimata;H. Watanabe
Glucuronyliransferase activity of KfiC from Escherichia coli strain K5 requires association of KfiA : KfiC and KfiA are essential enzymes for production of K5 polysaccharide, N-acetylheparosan
大肠杆菌菌株 K5 的 KfiC 的葡萄糖醛酸转移酶活性需要 KfiA 的结合:KfiC 和 KfiA 是生产 K5 多糖、N-乙酰肝素的必需酶
DOI:
--
发表时间:
2010
期刊:
J Biol Chem 285
影响因子:
--
作者:
[Sugiura, N., et al.]
通讯作者:
et al.
Cartilaginous features in matrix-producing carcinoma of the breast : four cases report with histochemical and immunohistolochemical analysis of matrix molecules.
产生基质的乳腺癌的软骨特征:四例报告基质分子的组织化学和免疫组织化学分析。
DOI:
--
发表时间:
2008
期刊:
Modern Pathol 21
影响因子:
--
作者:
[Kusafuka K, Muramatsu K, Kasami M, Kuriki K, Hirobe K, Hayashi I, Watanabe H, Hiraki Y, Shukunami C, Mochizuki T, Kameya T]
通讯作者:
Kameya T
Crucial role of vinexin for keratinocyte migration and epidermal wound healing in vivo
vinexin 对角质形成细胞迁移和体内表皮伤口愈合的关键作用
DOI:
--
发表时间:
2010
期刊:
Exp Cell Res (In press)
影响因子:
--
作者:
[Ito T, et al.]
通讯作者:
et al.
共 26 条
Role of proteoglycans in diseases: Regulation of cell behavior and maintenance of tissue structure
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批准号:25293096
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.15万
-
财政年份:2013
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负责人:WATANABE Hideto
-
依托单位:
Roles of versican in development and maintenance of hair follicles
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批准号:23659556
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2011
-
负责人:WATANABE Hideto
-
依托单位:
In vivo function of versican : Analysis of knockin mice
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批准号:17590361
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2005
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负责人:WATANABE Hideto
-
依托单位:
The Role of proteoglycans in chondrocyte differentiation of mesenchymal stem cells
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批准号:15590355
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:WATANABE Hideto
-
依托单位:
Cartilage Tissue Engineering Using Chondrogenic Cell Line N1511
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批准号:13670231
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2001
-
负责人:WATANABE Hideto
-
依托单位:
海外基金