Roles of versican in development and maintenance of hair follicles

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Versican (Vcan) is a large chondroitin sulfate proteoglycan of the extracellular matrix, which is transiently expressed in mesenchymal condensation areas such as cartilage primordium and dermal papilla. Here, we aimed to investigate the role of Vcan in development and maintenance of hair follicles. Though we performed intradermal injection of adenovirus expressing cre into Vcan<flox/flox> mice, we could not ablate its expression in dermal papilla cells. Currently, we are planning to generate Corin-cre; Vcan<flox/flox> mice, which lack Vcan expression in dermal papillae.