Evaluation of effects of salt reduction on blood pressure and behavior with genetic polymorphism information

利用遗传多态性信息评价减盐对血压和行为的影响

• 批准号: 19390173
• 负责人: 宮木 幸一
• 金额: $ 8.15万
• 依托单位: Keio University (2008-2009)Kyoto University (2007)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390173/
• 关键词: 成人保健; テイラーメイド予防; 遺伝子多型; 減塩介入; 行動理論; 高血圧; 減塩指導; SNP; 行動変容; ランダム化比較試験; 質問票調査

We evaluated the effects of our salt reduction intervention developed by the behavioral theory on blood pressure and behavior with genetic polymorphism information. We assessed the interaction of salt intake and genetic polymorphisms selected by candidate gene approach and Genome Wide Association Studies in Japanese population. Risk allele score of our results showed significant linear association with blood pressure. Information of polymorphism which affects blood pressure and the responsiveness to the salt reduction was gained which will be useful for future tailor-made prevention of hypertension.

我们利用遗传多态性信息评估了行为理论对血压和行为的减盐干预的效果。我们通过候选基因方法和全基因组关联研究在日本人群中评估了盐摄入量与遗传多态性的相互作用。风险等位基因评分与血压呈显著的线性相关。获得影响血压及对减盐反应的多态性信息，为今后的高血压针对性预防提供依据。

项目成果

Increasing the number of SNPs loci does not necessarily improve prediction power at least in the comparison of MTHFRSNP and haplotypes.

至少在 MTHFRSNP 和单倍型的比较中，增加 SNP 位点的数量并不一定会提高预测能力。

• 发表时间: 2008
• 期刊: Journal of Epidemiology 18
• 作者: Miyaki K;Takahashi Y;Song Y;Zhang L;Muramatsu M;Nakayama T.
• 通讯作者: Nakayama T.

The interaction between the IL6R genotype and dietary energy intake on abdominal obesity in Japanese men.

IL6R 基因型与膳食能量摄入之间的相互作用对日本男性腹部肥胖的影响。

• 发表时间: 2007
• 期刊: Metabolism 56
• 作者: Song Y;Miyaki K;Araki J;Zhang L;Omae K;Muramatsu M
• 通讯作者: Muramatsu M

Salt reduction intervention in workplace based on behavioral theories -Rationale and desien of a randomized controlled trial-

基于行为理论的工作场所减盐干预-随机对照试验的理由和设计-

• 发表时间: 2010
• 作者: Miyaki K;Muramatsu M;et al.
• 通讯作者: et al.

日本人男性におけるProstacyclin Synthase遺伝子多型と高血圧との関連性宋毅シュアン

前列环素合酶基因多态性与日本男性高血压的关联宋一栓

• 发表时间: 2007
• 作者: 宮木幸一;荒木淳吾;張玲;タンウー;中山健夫;村松正明
• 通讯作者: 村松正明

Influence of CYP11B2 Gene Polymorphism on the Prevalence of Hypertension and the Blood Pressure in Japanese Men: Interaction with Dietary Salt Intake

• DOI: 10.1159/000150006
• 发表时间: 2008-08
• 期刊: Lifestyle Genomics
• 影响因子: 2.6
• 作者: Yixuan Song;K. Miyaki;J. Araki;Ling Zhang;Yoshimitsu Takahashi;T. Nakayama;M. Muramatsu