Mechanism of inflammation-associated gastro-intestinal carcinogenesis

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NF-kB/IKK and JNK pathways are important cell signaling pathways that regulate the gene cluster associated with the inflammation, apoptosis, and cell proliferation. Therefore it is suggested that these pathways play important roles of the development or progression of carcinomas. We used the mouse models and examined those functions in the gastrointestinal cancers. Cancer development was inhibited in the knockout mouse of NF-kB/IKK and JNK in the stomach cancer model. In addition, the inflammation-associated cancer of colon was inhibited by the IKK inhibitor. In summary, NF-kB/IKK and JNK were should be important for the generation or progression of gastrointestinal cancers and will become the treatment targets.