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Roles of NF-kappaB activation in gastrointestinal tumorigenesis

Roles of NF-kappaB activation in gastrointestinal tumorigenesis
NF-κB 激活在胃肠道肿瘤发生中的作用
批准号:
22300317
负责人:
MAEDA Shin
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
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中文摘要
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英文摘要
It is thought that NF-kappaB activation is one of the important signal transduction systems for inflammation-related carcinogenesis. We analyzed the relationship between the NF-kappaB activation and gastrointestinal cancer development.The activation was observed in many gastrointestinal cancers. Using in vitro culture system and mouse model, NF-kappaB activation was an important malignant factor for gastric and pancreatic cancers, suggesting that inhibition of NF-kappaB activity may become adrug target.
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会议论文
Nuclear IKKβ phosphorylates ATM in response to genotoxic stimuli
核 IKKβ 磷酸化 ATM 以响应基因毒性刺激
DOI: --
发表时间: 2012
期刊:
影响因子: --
作者: [Sakamoto K, Hikiba Y, Hirata Y, Akanuma M, Kamata H, Maeda S]
通讯作者: Maeda S
Requirement for IKKB in a Mouse Modelof Pancreatic Ductal Adenocarcinoma
胰腺导管腺癌小鼠模型中 IKKB 的要求
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Maeda S, Hikiba Y, Sakamoto K, Okamoto M Nakagawa H, Hirata Y, Hayakawa Y, Nakata W, Ijichi H, Omata M]
通讯作者: Omata M
DOI: 10.3892/mmr.2011.545
发表时间: 2011-11-01
期刊: MOLECULAR MEDICINE REPORTS
影响因子: 3.4
作者: [Maeda, Shin, Hikiba, Yohko, Akanuma, Masao]
通讯作者: Akanuma, Masao
Colon cancer-derived factors activate NF-kB in myeloid cells via TLR2 to linkinflammation and tumorigenesis
结肠癌衍生因子通过 TLR2 激活骨髓细胞中的 NF-kB,将炎症与肿瘤发生联系起来
DOI: --
发表时间: 2011
期刊: Mol Med Report
影响因子: --
作者: [Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Akanuma M]
通讯作者: Akanuma M
27
    Establishment of a new gastric carcinogenesis model based on epigenetic changes
    • 批准号:
      19K08373
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2019
    • 负责人:
      MAEDA Shin
    • 依托单位:
    Analysis of signaling pathways for liver cancer stem cell maintenance
    • 批准号:
      25290045
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $10.9万
    • 财政年份:
      2013
    • 负责人:
      MAEDA Shin
    • 依托单位:
    Mechanism of inflammation-associated gastro-intestinal carcinogenesis
    Treatment of advanced liver cancer targeting tumor and tumor-related markers
    • 批准号:
      17016016
    • 项目类别:
      Grant-in-Aid for Scientific Research on Priority Areas
    • 资助金额:
      $45.76万
    • 财政年份:
      2005
    • 负责人:
      MAEDA Shin
    • 依托单位:
    海外基金