Roles of NF-kappaB activation in gastrointestinal tumorigenesis
Roles of NF-kappaB activation in gastrointestinal tumorigenesis
批准号:
22300317
负责人:
MAEDA Shin
金额:
$10.98万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
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英文摘要
It is thought that NF-kappaB activation is one of the important signal transduction systems for inflammation-related carcinogenesis. We analyzed the relationship between the NF-kappaB activation and gastrointestinal cancer development.The activation was observed in many gastrointestinal cancers. Using in vitro culture system and mouse model, NF-kappaB activation was an important malignant factor for gastric and pancreatic cancers, suggesting that inhibition of NF-kappaB activity may become adrug target.
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Nuclear IKKβ phosphorylates ATM in response to genotoxic stimuli
核 IKKβ 磷酸化 ATM 以响应基因毒性刺激
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Sakamoto K, Hikiba Y, Hirata Y, Akanuma M, Kamata H, Maeda S]
通讯作者:
Maeda S
Requirement for IKKB in a Mouse Modelof Pancreatic Ductal Adenocarcinoma
胰腺导管腺癌小鼠模型中 IKKB 的要求
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Maeda S, Hikiba Y, Sakamoto K, Okamoto M Nakagawa H, Hirata Y, Hayakawa Y, Nakata W, Ijichi H, Omata M]
通讯作者:
Omata M
DOI:
10.3892/mmr.2011.545
发表时间:
2011-11-01
期刊:
MOLECULAR MEDICINE REPORTS
影响因子:
3.4
作者:
[Maeda, Shin, Hikiba, Yohko, Akanuma, Masao]
通讯作者:
Akanuma, Masao
Colon cancer-derived factors activate NF-kB in myeloid cells via TLR2 to linkinflammation and tumorigenesis
结肠癌衍生因子通过 TLR2 激活骨髓细胞中的 NF-kB,将炎症与肿瘤发生联系起来
DOI:
--
发表时间:
2011
期刊:
Mol Med Report
影响因子:
--
作者:
[Maeda S, Hikiba Y, Sakamoto K, Nakagawa H, Hirata Y, Hayakawa Y, Akanuma M]
通讯作者:
Akanuma M
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kamata T, Kajla S, Abdus M, Nagasawa A, Zhang Y, Kato M, Tatsuno I, Maeda S]
通讯作者:
Maeda S
共 27 条
Establishment of a new gastric carcinogenesis model based on epigenetic changes
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批准号:19K08373
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2019
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负责人:MAEDA Shin
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依托单位:
Analysis of signaling pathways for liver cancer stem cell maintenance
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批准号:25290045
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.9万
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财政年份:2013
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负责人:MAEDA Shin
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依托单位:
Mechanism of inflammation-associated gastro-intestinal carcinogenesis
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批准号:19390205
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.81万
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财政年份:2007
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负责人:MAEDA Shin
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依托单位:
Treatment of advanced liver cancer targeting tumor and tumor-related markers
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批准号:17016016
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$45.76万
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财政年份:2005
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负责人:MAEDA Shin
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依托单位:
海外基金