Treatment of advanced liver cancer targeting tumor and tumor-related markers

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This project has attempted to find out new biological markers relating to hepato-cellular carcinoma (HCC) and develop new treatment protocol against HCC. To analyze many clinical samples, some experimental systems including Genechip, Protein array, and Mass spectrometry were applied to the assay, and the data was comprehensively analyzed. As the achievements in this period, we found that 1) The tumor incidence rate is related to the serum concentration of IL-6 in women, 2) Platelet Factor 4(PF4), Angiogenin(ANG), TIMP-1, Serpin E1(PAI-1), VEGF are upregulated and Hip is decreased in HCC, 3) In the serum after the ablation of HCC, proapolipoprotein, α2-HS glycoprotein, apolipoprotein A-IV precursor, PRO1708/PRO2044 are decreased and leucine-rich α2-glycoprotein、α1-antitrypsin are increased, 4) High DCP can be a prognostic factor of PVTT . In addition, 5) We designed and performed the randomized control study about the effect of VitaminK treatment against HCC recurrence.