Treatment of advanced liver cancer targeting tumor and tumor-related markers

靶向肿瘤及肿瘤相关标志物治疗晚期肝癌

• 批准号: 17016016
• 负责人: MAEDA Shin
• 金额: $ 45.76万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016016/
• 关键词: 癌; 遺伝子; ゲノム; 炎症; プロテオミクス; 臨床; プロオミクス; 生体マーカー; 肝癌

This project has attempted to find out new biological markers relating to hepato-cellular carcinoma (HCC) and develop new treatment protocol against HCC. To analyze many clinical samples, some experimental systems including Genechip, Protein array, and Mass spectrometry were applied to the assay, and the data was comprehensively analyzed. As the achievements in this period, we found that 1) The tumor incidence rate is related to the serum concentration of IL-6 in women, 2) Platelet Factor 4(PF4), Angiogenin(ANG), TIMP-1, Serpin E1(PAI-1), VEGF are upregulated and Hip is decreased in HCC, 3) In the serum after the ablation of HCC, proapolipoprotein, α2-HS glycoprotein, apolipoprotein A-IV precursor, PRO1708/PRO2044 are decreased and leucine-rich α2-glycoprotein、α1-antitrypsin are increased, 4) High DCP can be a prognostic factor of PVTT . In addition, 5) We designed and performed the randomized control study about the effect of VitaminK treatment against HCC recurrence.

本课题旨在寻找与肝癌相关的新的生物学标志物，开发新的肝癌治疗方案。为了分析大量的临床样本，将基因芯片、蛋白质芯片和质谱等实验系统应用于检测，并对数据进行综合分析。本研究发现：1）女性肿瘤发病率与血清IL-6浓度有关; 2）HCC患者血小板因子4（PF 4）、血管生成素（ANG）、TIMP-1、Serpin E1（派-1）、VEGF表达上调，Hip表达降低; 3）HCC消融术后血清载脂蛋白原、α2-HS糖蛋白、载脂蛋白A-IV前体、PRO 1708/PRO 2044降低，富含亮氨酸的α2-糖蛋白、α1-抗胰蛋白酶升高。另外，我们设计并实施了维生素K治疗对肝癌复发影响的随机对照研究。

项目成果

Negative regulation of intracellular hepatitis C virus replication by interferon regulatory factor 3

• DOI: 10.1007/s00535-006-1842-x
• 发表时间: 2006-08
• 期刊: Journal of Gastroenterology
• 影响因子: 6.3
• 作者: T. Yamashiro;N. Sakamoto;M. Kurosaki;N. Kanazawa;Y. Tanabe;M. Nakagawa;Cheng-Hsin Chen;Yasuhiro Itsui-Ya

Treatment strategy of hepatitis C in Japan

日本丙型肝炎治疗策略

• 发表时间: 2007
• 作者: IGuo;X.;et.al.;Enomoto N
• 通讯作者: Enomoto N

Gene expressions associated with chemosensitivity in human hepatoma cells.

• 发表时间: 2007-03
• 期刊: Hepato-gastroenterology
• 作者: Y. Hoshida;M. Moriyama;M. Otsuka;N. Kato;Hiroyoshi Taniguchi;Y. Shiratori;N. Seki;M. Omata

Radiotherapy for lymph node metastases in patients with hepatocellular carcinoma: Retrospective study

• DOI: 10.1111/j.1440-1746.2006.04450.x
• 发表时间: 2007-04-01
• 期刊: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
• 影响因子: 4.1
• 作者: Yamashita, Hideomi;Nakagawa, Keiichi;Ohtomo, Kuni
• 通讯作者: Ohtomo, Kuni

Ikappa B kinasebeta/nuclear factor-kappaB activation controls the development of liver metastasis by way of interleukin-6 expression

Ikappa B 激酶β/核因子-kappaB 激活通过白细胞介素 6 表达控制肝转移的发展

• 发表时间: 2009
• 期刊: Hepatology 50
• 作者: Maekawa S;Enomoto N.;Maeda S
• 通讯作者: Maeda S