Development of a microreactor for radiosynthesis of ^<18>F-probes

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An automated system was developed for concentration of aqueous ^<18>F-fluoride produced in ^<18>O-water with a cyclotron. It was electrochemically trapped in a disposable microflow cell chip and then released as a complex with K+-K.222 in a small portion of an aprotic solvent (<60μL) such as acetonitrile and DMSO. Thus, the concentrated solution was mixed with a precursor solution followed by passing through a heated microchannel to synthesize ^<18>F-FDG, FLT and FMISO. Reaction time, temperature and solvent were examined for optimizing ^<18>F-substitution reactions. It was observed that microreactor radiosynthesis was very rapid and efficient as reported.