Development of a total microreactor system for radiosynthesis of^<18>F-labeled PET probes

开发用于放射合成^ 18 F-标记的PET探针的总微反应器系统

• 批准号: 22390228
• 负责人: IWATA Ren
• 金额: $ 11.73万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390228/
• 关键词: 分子イメージング; マイクロリアクター; 標識合成; PET; 標識プローブ; F-18; 放射性薬剤; 自動合成

In order to utilize electrochemically concentrated [^<18>F]fluoride in microreactor radiosynthesis of ^<18>F-labeled probes, we developed a total system for carrying out the whole procedures from separation of [^<18>F]fluoride to purification of a ^<18>F-labeled probe based on the following techniques: to improve the concentration of [^<18>F]fluoride with a newly designed chip; to develop a new evaporation chip for on-line concentration of a reaction product solution; to develop a rapid, efficient method for purifying a final product with a solid phase extraction column. We demonstrated that the decrease in concentration of [^<18>F]fluoride in acetonitrile was mainly caused by diffusion in transfer tubing and that the evaporation chip worked efficiently under optimized conditions.

为了利用电化学浓缩的[^<18>F]氟化物在微反应器中放射合成<18>~（125）F标记探针，我们开发了一个完整的系统，用于进行从分离~（125）F标记<18>探针到纯化<18>的整个过程，该系统基于以下技术：用新设计的芯片提高~（125）F标记探针的浓度<18>;开发用于在线浓缩反应产物溶液的新蒸发芯片;开发用固相萃取柱纯化最终产物的快速、有效方法。我们证明了乙腈中[^ F]氟化物浓度的降低<18>主要是由转移管中的扩散引起的，并且蒸发芯片在优化条件下有效地工作。

项目成果

A modified method of 3D-SSP analysis for amyloid PET imaging using [11C]BF-227

• DOI: 10.1007/s12149-011-0518-7
• 发表时间: 2011-07
• 期刊: Annals of Nuclear Medicine
• 影响因子: 2.6
• 作者: T. Kaneta;N. Okamura;S. Minoshima;K. Furukawa;M. Tashiro;S. Furumoto;R. Iwata;H. Fukuda;Shoki Takahashi;K. Yanai;Y. Kudo;H. Arai

Synthesis of [^(11)C]interleukin 8 using a cell-free translation system and l-[^(11)C]methionine

使用无细胞翻译系统和 l-[^(11)C]蛋氨酸合成 [^(11)C]白细胞介素 8

• DOI: 10.1016/j.nucmedbio.2011.07.005
• 发表时间: 2012
• 期刊: Nucl Med Biol
• 影响因子: 3.1
• 作者: Harada R;Furumoto S;Y oshikawa T;Ishikawa Y;Shibuya K;Okamura N;Iwata R;Y anai K
• 通讯作者: Y anai K

[N-Methyl-11C]Choline by on-columnreaction: a study on [^<11>C]CH_3I incorporation and the residual amount of precursor in the product

柱上反应法测定[N-甲基-11C]胆碱：[^11C]CH_3I 掺入及产物中前体残留量的研究

• DOI: 10.1002/jlcr.1838
• 发表时间: 2011
• 期刊: J. Label. Compd. Radiopharm
• 作者: Bogni A.;Crispu O.;Fugazza L.;Cucchi C.;Laera L.;Iwata R.;CrippaF.;Bombardieri E.;Pascali C.
• 通讯作者: Pascali C.

Reactivity of Electrochemically Concentrated Anhydrous [^<18>p]Fluoride for Microfluidic Radiosynthesis of 18F-labeled Compounds

电化学浓缩的无水[^ 18p]氟化物用于18F标记化合物的微流体放射合成的反应性

• 发表时间: 2012
• 期刊: Appl.Radiat.Isot.
• 作者: Wong R.;Iwata R.;Saiki H.;Furumoto S.;Ishikawa Y.;Ozeki E
• 通讯作者: Ozeki E

Reactivity of electrochemically concentrated anhydrous [^<18>F]fluoride for microfluidic radiosynthesis of ^<18>F-labeled compounds

电化学浓缩的无水[^ 18 F]氟化物用于^ 18 F-标记化合物的微流体放射合成的反应性

• DOI: 10.1016/j.apradiso.2011.09.022
• 发表时间: 2012
• 期刊: Appl. Radiat. Isot
• 作者: Wong R.;Iwata R.;Saiki H.;Furumoto S.;Ishikawa Y.;Ozeki E.
• 通讯作者: Ozeki E.