Omics analysis of cancer vessel abnormalities as therapeutic targets
Omics analysis of cancer vessel abnormalities as therapeutic targets
批准号:
19390346
负责人:
TANAKA Shinji
金额:
$11.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
Intraoperative contrast-enhanced ultrasonography revealed the relationship between the dynamic pattern of angiogenesis in hepatocellular carcinoma (HCC) and the cancer cell differentiation. According to the cDNA microarray, the pattern of angiogenesis was closely associated with the expression of Angiopoietin-2, one of the therapeutic targets evaluated in clinical trials for cancers. Along with the angiogenesis, vascular invasion of cancer cells is started and progressed to metastatic steps. Further transcriptional network analysis revealed the closed relationship between the Aurora B pathways and the vascular-invasion phenotype of HCC. Our preclinical studies using the Aurora-targeted agents indicated novel adjuvant therapy for aggressive HCC.
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Small agarose microcapsules with cell-enclosing hollow core for cell therapy : Transplantation of ifosfamide-activating cells to the mice with pre-established subcutaneous tumor.
用于细胞治疗的具有细胞封闭空心的小琼脂糖微胶囊:将异环磷酰胺激活细胞移植到预先形成皮下肿瘤的小鼠中。
DOI:
--
发表时间:
2009
期刊:
Cell Transplantation 18
影响因子:
--
作者:
[Sakai S, Hashimoto I, Tanaka S.Salmons B.Kawakami K.]
通讯作者:
Tanaka S.Salmons B.Kawakami K.
Gene expression phenotypes of vascular invasion and novel molecular targets of hepatocellular carcinoma (English Workshop)
血管侵犯的基因表达表型和肝细胞癌的新分子靶点(英语研讨会)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Tanaka S, Mogushi K, Aihara A, Yasen M, Mizushima H, Miki Y, Inazawa J, Tanaka H. Arii S.]
通讯作者:
Tanaka H. Arii S.
シンポジウム「肝癌の分子標的治療」肝細胞癌の再発規定分子解析に基づく新規分子標的の同定
研讨会“肝癌的分子靶向治疗”基于肝细胞癌复发规律的分子分析识别新的分子靶点
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[田中真二, 藍原有弘, 有井滋樹]
通讯作者:
有井滋樹
肝癌の分子標的治療(シンポジウム)
肝癌分子靶向治疗(研讨会)
DOI:
--
发表时间:
2007
期刊:
影响因子:
--
作者:
[田中真二, 藍原有弘, Mahmut Yasen, 茂櫛薫, 工藤篤, 中村典明, 伊東浩次, 稲澤譲治, 三木義男, 田中博, 有井滋樹]
通讯作者:
有井滋樹
DOI:
10.1016/j.jamcollsurg.2008.10.031
发表时间:
2009-03-01
期刊:
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
影响因子:
5.2
作者:
[Tanaka, Shinji, Mogushi, Kaoru, Arii, Shigeki]
通讯作者:
Arii, Shigeki
共 54 条
学校安全の推進の為の組織的対応力の向上を目指した校内研修プログラムの開発
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批准号:21H03974
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.28万
-
财政年份:2021
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负责人:TANAKA Shinji
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依托单位:
安全に関する資質・能力を身に着けることを目指した、安全教育カリキュラムの構築
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批准号:19H00081
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项目类别:Grant-in-Aid for Encouragement of Scientists
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资助金额:$0.33万
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负责人:TANAKA Shinji
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依托单位:
Virtue Ethics in Plato's Politeia
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批准号:18K00011
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.25万
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财政年份:2018
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负责人:TANAKA Shinji
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依托单位:
Develoment of advanced therapy targeting tumor heterogeneity in refractory cancers
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批准号:16H02670
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.28万
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财政年份:2016
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负责人:TANAKA Shinji
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依托单位:
Development of chiral picolinic acid-type ligand and application for saymmetric catalysis
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批准号:25410112
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.33万
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财政年份:2013
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负责人:TANAKA Shinji
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依托单位:
Experimental verification of the model of concentration change in lubricating film by measuring the distribution of the refrigerant concentration dissolved in the lubricating film
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批准号:23560154
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.41万
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财政年份:2011
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负责人:TANAKA Shinji
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依托单位:
Study on the establishment of the unified international NBI magnification classification for colorectal tumor
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批准号:22590762
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.58万
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财政年份:2010
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负责人:TANAKA Shinji
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依托单位:
Catalytic Asymmetric Synthesis of Chiral Cyclic Ethers
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批准号:22750088
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2010
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负责人:TANAKA Shinji
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依托单位:
Innovation of cancer treatment based on the refractory mechanism
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批准号:22249050
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$30.7万
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财政年份:2010
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负责人:TANAKA Shinji
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依托单位:
Truth and the structure of Socratic dialectic
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批准号:21520008
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.83万
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财政年份:2009
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负责人:TANAKA Shinji
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依托单位:
Analysis of novel angiogenesis-related genes and development of tumor dormancy therapy
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批准号:17390371
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.54万
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财政年份:2005
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负责人:TANAKA Shinji
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依托单位:
Study on Psyche' in the Ancient Greek Philosophy
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批准号:17320004
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.15万
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财政年份:2005
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负责人:TANAKA Shinji
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依托单位:
Analysis of newly identified anglogenic genes and the signal inhibition for tumor dormancy therapy
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批准号:14571141
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2002
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负责人:TANAKA Shinji
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依托单位:
Socratic Inquiry in Plato's Early Philosophy : Dialectic Structure and its significance of today
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批准号:13610039
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.02万
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财政年份:2001
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负责人:TANAKA Shinji
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依托单位:
Regulation of multiple angiogenic signaling and development of cancer-specific gene therapy
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批准号:12671164
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2000
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负责人:TANAKA Shinji
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依托单位:
Clinicopathologic and genetic analysis on histogenesis and development of colorectal carcinoma
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批准号:10670478
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.05万
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财政年份:1998
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负责人:TANAKA Shinji
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依托单位:
Clinicopathologic and molecular biologic study on histogenesis and development of colorectal carcinoma
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批准号:08670596
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.15万
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财政年份:1996
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负责人:TANAKA Shinji
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依托单位:
国内基金
海外基金
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基于HIF-1α乳酸化修饰探讨桃红四物汤调控BMSCs-H型血管新生轴促进骨折愈合的分子机制研究
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批准号:2026JJ80362
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批准年份:2026
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基于多组学揭示乳酸微环境中SPP1+肺癌细胞和SELE+内皮细胞促进血管新生的机制研究
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高糖诱导成纤维细胞外泌体GTF2H2介导血管新生抑制致糖尿病创面愈合障碍的机制研究
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活血荣络方诱导周细胞-内皮细胞间线粒体转移促脑梗死后血管新生的机制研究
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黄芪当归碳量子点调控高糖受损内皮祖细胞乳酸代谢促糖尿病下肢缺血后血管新生的作用机制研究
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PKCδ/EGR1/PHGDH 轴调控丝氨酸代谢促进内皮细胞衰老在糖尿病创面血管新生障碍中的机制研究
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