Omics analysis of cancer vessel abnormalities as therapeutic targets

作为治疗靶点的癌症血管异常的组学分析

• 批准号: 19390346
• 负责人: TANAKA Shinji
• 金额: $ 11.98万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19390346/
• 关键词: 肝臓外科学; 血管新生; 血管侵襲; 肝癌; 再発; Aurora B kinase; 前臨床試験; histon H3; アポトーシス; Angiopoietin; Tie2; cDNA microarray; CGH array; Aurora Kinase; microRNA microarray

Intraoperative contrast-enhanced ultrasonography revealed the relationship between the dynamic pattern of angiogenesis in hepatocellular carcinoma (HCC) and the cancer cell differentiation. According to the cDNA microarray, the pattern of angiogenesis was closely associated with the expression of Angiopoietin-2, one of the therapeutic targets evaluated in clinical trials for cancers. Along with the angiogenesis, vascular invasion of cancer cells is started and progressed to metastatic steps. Further transcriptional network analysis revealed the closed relationship between the Aurora B pathways and the vascular-invasion phenotype of HCC. Our preclinical studies using the Aurora-targeted agents indicated novel adjuvant therapy for aggressive HCC.

术中超声造影显示肝细胞癌（HCC）血管生成的动态模式与癌细胞分化程度的关系。根据cDNA微阵列，血管生成的模式与血管生成素-2的表达密切相关，血管生成素-2是癌症临床试验中评估的治疗靶点之一。沿着血管生成，癌细胞的血管侵入开始并进展到转移步骤。进一步的转录网络分析揭示了Aurora B通路与HCC血管侵袭表型之间的密切关系。我们使用Aurora靶向药物的临床前研究表明了侵袭性HCC的新辅助治疗。

项目成果

Small agarose microcapsules with cell-enclosing hollow core for cell therapy : Transplantation of ifosfamide-activating cells to the mice with pre-established subcutaneous tumor.

用于细胞治疗的具有细胞封闭空心的小琼脂糖微胶囊：将异环磷酰胺激活细胞移植到预先形成皮下肿瘤的小鼠中。

• 发表时间: 2009
• 期刊: Cell Transplantation 18
• 作者: Sakai S;Hashimoto I;Tanaka S.Salmons B.Kawakami K.
• 通讯作者: Tanaka S.Salmons B.Kawakami K.

Gene expression phenotypes of vascular invasion and novel molecular targets of hepatocellular carcinoma (English Workshop)

血管侵犯的基因表达表型和肝细胞癌的新分子靶点（英语研讨会）

• 发表时间: 2008
• 作者: Tanaka S;Mogushi K;Aihara A;Yasen M;Mizushima H;Miki Y;Inazawa J;Tanaka H. Arii S.
• 通讯作者: Tanaka H. Arii S.

シンポジウム「肝癌の分子標的治療」肝細胞癌の再発規定分子解析に基づく新規分子標的の同定

研讨会“肝癌的分子靶向治疗”基于肝细胞癌复发规律的分子分析识别新的分子靶点

• 发表时间: 2008
• 作者: 田中真二;藍原有弘;有井滋樹
• 通讯作者: 有井滋樹

肝癌の分子標的治療(シンポジウム)

肝癌分子靶向治疗（研讨会）

• 发表时间: 2007
• 作者: 田中真二;藍原有弘;Mahmut Yasen;茂櫛薫;工藤篤;中村典明;伊東浩次;稲澤譲治;三木義男;田中博;有井滋樹
• 通讯作者: 有井滋樹

Surgical Contribution to Recurrence-Free Survival in Patients with Macrovascular-Invasion-Negative Hepatocellular Carcinoma

• DOI: 10.1016/j.jamcollsurg.2008.10.031
• 发表时间: 2009-03-01
• 期刊: JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
• 影响因子: 5.2
• 作者: Tanaka, Shinji;Mogushi, Kaoru;Arii, Shigeki
• 通讯作者: Arii, Shigeki