New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor
New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor
批准号:
19390427
负责人:
KIKKAWA Fumitaka
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009
中文摘要
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英文摘要
We demonstrated the significance of EMT and EMT inducible transcriptional factor in the metastasis of ovarian cancer. In addition, TWIST, one of the EMT inducible factors positively influenced the formation of peritoneal metastasis or the resistance to anti-neoplastic agents in this tumor. Furthermore, even in the recurrent ovarian cancer we showed the possible link between EMT and increasing local metastatic potential. Our study suggested the EMT inducible factor targeting therapy may lead to a new approach for the treatment of refractory ovarian cancer.
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今日の治療指針 卵巣腫瘍(良性、境界悪性、悪性)
今日治疗指南 卵巢肿瘤(良性、交界性恶性、恶性)
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Ino K, Kikkawa F, 吉川史隆]
通讯作者:
吉川史隆
DOI:
10.1186/1471-2407-7-140
发表时间:
2007-07-27
期刊:
BMC cancer
影响因子:
3.8
作者:
[Terauchi M, Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F]
通讯作者:
Kikkawa F
DOI:
10.1016/j.ygyno.2009.07.015
发表时间:
2009-11-01
期刊:
GYNECOLOGIC ONCOLOGY
影响因子:
4.7
作者:
[Inaba, Tomoko, Ino, Kazuhiko, Kikkawa, Fumitaka]
通讯作者:
Kikkawa, Fumitaka
DOI:
10.1007/s10585-007-9079-5
发表时间:
2007-10-01
期刊:
CLINICAL & EXPERIMENTAL METASTASIS
影响因子:
4
作者:
[Tsukamoto, Hirohisa, Shibata, Kiyosumi, Kikkawa, Fumitaka]
通讯作者:
Kikkawa, Fumitaka
シスプラチン耐性卵黄嚢腫瘍細胞株の樹立と耐性機序の検討
顺铂耐药卵黄囊肿瘤细胞系的建立及耐药机制研究
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[柴田清住、吉川史隆, 他]
通讯作者:
他
共 33 条
An attempt to identify new antigens recognized by tumor-specific cytotoxic T lymphocytes using a HLA-modified ovarian cancer cell line as an artificial antigen presenting cell
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批准号:24659727
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2012
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负责人:KIKKAWA Fumitaka
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依托单位:
Combination of stem cell research and immunotherapy in gynecologic cancer
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批准号:22390311
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$11.98万
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财政年份:2010
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负责人:KIKKAWA Fumitaka
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依托单位:
Characteristic of gynecologic cancer stem cell and Epithelial-Mesenchymal Transition
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批准号:21659383
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.18万
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财政年份:2009
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负责人:KIKKAWA Fumitaka
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依托单位:
New strategy for gynecologic cancer targeting of membrane-bound protease
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批准号:16591654
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.37万
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财政年份:2004
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负责人:KIKKAWA Fumitaka
-
依托单位:
Interaction between ovarian carcinoma cells and mesothelial cells in peritoneal dissemination
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批准号:13671706
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2001
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负责人:KIKKAWA Fumitaka
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依托单位:
Identification and Cloning of an inhibitor of Cancer Metastasis and Invasion
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批准号:08671882
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$1.41万
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财政年份:1996
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负责人:KIKKAWA Fumitaka
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依托单位:
Identification and Cloning for cisplatin Resistance gene
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批准号:06671641
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.41万
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财政年份:1994
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负责人:KIKKAWA Fumitaka
-
依托单位:
Role of Oncogene and Cytochrome P450 in Carcinogenesis of Gynecologic carcinoma
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批准号:03670776
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
-
财政年份:1991
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负责人:KIKKAWA Fumitaka
-
依托单位: