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New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor

New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor
针对EMT诱导转录因子的增强卵巢癌化疗敏感性和降低转移潜力的新策略
批准号:
19390427
负责人:
KIKKAWA Fumitaka
金额:
$11.9万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
We demonstrated the significance of EMT and EMT inducible transcriptional factor in the metastasis of ovarian cancer. In addition, TWIST, one of the EMT inducible factors positively influenced the formation of peritoneal metastasis or the resistance to anti-neoplastic agents in this tumor. Furthermore, even in the recurrent ovarian cancer we showed the possible link between EMT and increasing local metastatic potential. Our study suggested the EMT inducible factor targeting therapy may lead to a new approach for the treatment of refractory ovarian cancer.
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会议论文
今日の治療指針 卵巣腫瘍(良性、境界悪性、悪性)
今日治疗指南 卵巢肿瘤(良性、交界性恶性、恶性)
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Ino K, Kikkawa F, 吉川史隆]
通讯作者: 吉川史隆
DOI: 10.1186/1471-2407-7-140
发表时间: 2007-07-27
期刊: BMC cancer
影响因子: 3.8
作者: [Terauchi M, Kajiyama H, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F]
通讯作者: Kikkawa F
DOI: 10.1016/j.ygyno.2009.07.015
发表时间: 2009-11-01
期刊: GYNECOLOGIC ONCOLOGY
影响因子: 4.7
作者: [Inaba, Tomoko, Ino, Kazuhiko, Kikkawa, Fumitaka]
通讯作者: Kikkawa, Fumitaka
DOI: 10.1007/s10585-007-9079-5
发表时间: 2007-10-01
期刊: CLINICAL & EXPERIMENTAL METASTASIS
影响因子: 4
作者: [Tsukamoto, Hirohisa, Shibata, Kiyosumi, Kikkawa, Fumitaka]
通讯作者: Kikkawa, Fumitaka
33
    An attempt to identify new antigens recognized by tumor-specific cytotoxic T lymphocytes using a HLA-modified ovarian cancer cell line as an artificial antigen presenting cell
    • 批准号:
      24659727
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
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    • 财政年份:
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    • 批准号:
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    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.18万
    • 财政年份:
      2009
    • 负责人:
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    • 批准号:
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    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
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    • 财政年份:
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    • 负责人:
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