Characteristic of gynecologic cancer stem cell and Epithelial-Mesenchymal Transition
Characteristic of gynecologic cancer stem cell and Epithelial-Mesenchymal Transition
批准号:
21659383
负责人:
KIKKAWA Fumitaka
金额:
$2.18万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
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英文摘要
The present study was designed to evaluate the tumor-formation ability of CD133+cells in ovarian Yolk sac tumor(YST) cell lines and to examine characteristics of CD133+cells such as cell growth, and invasiveness. Furthermore, we investigated interactions between peritoneal mesothelial cells and stem cell of YST(SC-YST) based on the hypothesis that peritoneal mesothelial cells have the potential to provide one of the niches for SC-YST. Our data suggest that peritoneal mesothelial cells have the potential to provide one of the niches for NOY1 cells. Interaction of peritoneal mesothelial cell and NOY1-CD133+cells induced Epithelial-Mesenchymal Transition in these cells.
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婦人科癌に対する特異的癌免疫療法-明細胞腺癌を対象としたGPC3特異的ペプチドワクチン療法の第I, II相臨床試験
妇科癌症特异性癌症免疫治疗——GPC3特异性肽疫苗治疗透明细胞腺癌的I期和II期临床试验
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[柴田清住, 吉川史隆]
通讯作者:
吉川史隆
Functional interaction between peritoneal mesothelial cells and stem cells of ovarian yolk sac tumor in peritoneal dissemination
腹膜播散中卵巢卵黄囊肿瘤腹膜间皮细胞与干细胞的功能相互作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Mitsui H, Shibata K, Suzuki S, Umezu T, Mizuno M, Kajiyama H, Kikkawa F]
通讯作者:
Kikkawa F
中面哲也卵巣明細胞腺がんに対するGPC3由来ペプチドワクチン療法の可能性
Tetsuya Nakamen GPC3 衍生肽疫苗治疗卵巢透明细胞腺癌的可能性
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[鈴木史朗, 吉川聡明, 廣澤友也, 柴田清住, 吉川史隆]
通讯作者:
吉川史隆
DOI:
10.1111/j.1349-7006.2010.01672.x
发表时间:
2010-10-01
期刊:
CANCER SCIENCE
影响因子:
5.7
作者:
[Suzuki, Shiro, Terauchi, Mikio, Kikkawa, Fumitaka]
通讯作者:
Kikkawa, Fumitaka
卵巣がん幹細胞と腹膜中皮細胞の相互作用
卵巢癌干细胞与腹膜间皮细胞的相互作用
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[松村寛子, 柴田清住, 梅津朋和, 梶山広明, 那波明宏, 吉川史隆]
通讯作者:
吉川史隆
共 10 条
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资助金额:$2.41万
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New strategy for the enhanced chemosensitivity and less metastatic potential of ovarian cancer targeting EMT inducible transcriptional factor
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New strategy for gynecologic cancer targeting of membrane-bound protease
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财政年份:2004
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负责人:KIKKAWA Fumitaka
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依托单位:
Interaction between ovarian carcinoma cells and mesothelial cells in peritoneal dissemination
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批准号:13671706
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2001
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Identification and Cloning of an inhibitor of Cancer Metastasis and Invasion
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资助金额:$1.41万
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依托单位:
Identification and Cloning for cisplatin Resistance gene
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资助金额:$1.41万
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依托单位:
Role of Oncogene and Cytochrome P450 in Carcinogenesis of Gynecologic carcinoma
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批准号:03670776
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财政年份:1991
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依托单位:
海外基金