Basic and clinical investigation of cerebral and sacral neuromodulation in the field of pediatric surgical diseases

神经调节是一种最新的技术，它将电流施加到大脑皮层或骶神经，以改善神经障碍。重复磁刺激是一种非侵入性技术，可以无痛地在体内感应电流。在动物研究的基础上，其中一个疗程包括以15赫兹的频率进行5秒的刺激，每次10次，间隔1分钟。我们对术后无不良反应(肛门直肠畸形24例，先天性巨结肠症10例，慢性便秘10例)的患儿进行了骶骨磁刺激(SMS)治疗。在3例对保守治疗无效的严重肠或膀胱功能障碍的术后患儿中，SMS有显著的改善，从而提示SMS作为一种新的神经调节治疗方式是有用的。

Neuromodulation is a recent technique where an electric current is applied to the cerebral cortex or the sacral nerves to improve neural disturbances. Repetitive magnetic stimulation represents a non-invasive technique to painlessly induce an electric current inside the body. Based on the animal studies, one treatment course consisted of stimulation delivered at 15Hz for 5 seconds 10 times over an interval of one minute. We performed sacral magnetic stimulation (SMS) in post-operative pediatric patients withoug any harmful events (anorectal anomalies 24 case, Hirschspurung disease 10 cases, and chronic constipation 10 cases). In three post-operative pediatric patients with severe bowel or bladder dysfunction refractory to conservative treatments, SMS induced a remarkable improvement, thereby suggesting usefulness of SMS as a new treatment modality of neuromodulation.