Establishment of the method to explore neural interaction between the sacrum and anorectum using a repetitive magnetic stimulation in children

儿童重复磁刺激探索骶骨与肛门直肠神经相互作用方法的建立

基本信息

批准号：
14370566
负责人：
KUBOTA Masayuki
金额：
$ 8.96万
依托单位：
Niigata University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

The intestinal activity is well known to be secondarily controlled by the central nervous, system through the sympathetic and parasympathetic systems. In the pelvic region, the sacral nervous system influences the bladder and rectoanal function. However, the sacro-anorectal neural interactions in these diseases remain unclear due to the absence of a proper examination modality. We therefore examined the usefulness of sacral magnetic stimulation as a new modality for examining sacro-anorectal interaction.Patients and Methods : Control data was obtained from 25 children without bowel dysmotility. 45 patients with chronic constipation (age range ; 1 m/o to 11 y/o), 8 pre-operative patients with Hirschsprung's disease (1 m/o to 6 y/o) and one female patient with MMIHS (1 y/o) were examined. Magnetic stimulation with a duration of one second delivered at 10 to 15Hz was applied at the S3 level using MagPro(Medtronic) with a figure eight coil while simultaneously performing the manometric rec … More ordings of the anorectal activity.Results : In the 45 patients with chronic constipation and one patient with MMIHS, the rectoanal reflex was demonstrated by balloon rectal dilatation in all patients. Control patients uniformly exhibited a biphasic response consisting of the initial contraction followed by a relaxation. On the other hand, the sphincter response to magnetic stimulation varied among the patients with chronic constipation including no response in 5 patients, a biphasic response of an initial rise followed by a decrease in the sphincter pressure in 36 patients and only a transient rise in pressure in two patient. The MMIHS patient exhibited a transient rise in the sphincter to magnetic stimulation. In eight pre-operative patients with Hirschsprung's disease, no rectoanal reflex was observed, however, the sphincter pressure increased due to magnetic stimulation in five patients, while three patients exhibited no recordable responses.Conclusion : These results suggest that the repetitive magnetic stimulation technique is a valuable modality for elucidating the neural interaction between the sacral nervous system and the anorectum, thereby suggesting its usefulness for obtaining a better understanding of the anorectal pathology. Less

众所周知，肠道活性是由中枢神经系统通过交感神经和副交感神经系统控制的次级。在骨盆区域，s骨神经系统会影响膀胱和正直功能。然而，由于没有适当的检查方式，这些疾病中的sacro-anor直肠神经相互作用尚不清楚。因此，我们研究了骨磁刺激的有用性，作为检查saCro-Anorectal互动的一种新方式。患者和方法：从没有肠内功能低下的25名儿童中获得了控制数据。 45例慢性便秘患者（年龄范围； 1 m/o至11 y/o），8例HIRSCHSPRUNG病前患者（1 m/o至6 y/o）和一名MMIHS（1 y/o）患者（1 y/o）。使用Magpro（Medtronic）在S3水平上使用八秒钟的磁模拟，并使用图八个线圈，同时执行操纵性恢复……厌食症的更多订单：在45例患者和一名患者的患者中，由45例患者进行了反射症状。对照患者统一暴露了由初始收缩，然后放松的双相反应。另一方面，对磁刺激的括约肌反应在慢性便秘患者中有所不同，其中包括5例无反应，初始上升的双相反应，随后36例患者的括约肌压力降低，两名患者的压力只有短暂的升高。 MMIHS患者暴露于括约肌的短暂上升到磁刺激。 In eight pre-operative patients with Hirschsprung's disease, no rectoanal reflex was observed, however, the sphincter pressure increased due to magnetic Stimulation in five patients, while three patients exposed no recordable responses.Conclusion : These results suggest that the repetitive magnetic stimulation technique is a valuable modality for elucidating the neural interaction between the sacral nervous system and the anorectum, thereby suggesting its usefulness for obtaining a更好地理解厌食症病理学。

项目成果

期刊论文数量（35）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Posterior sagittal anorectoplasty for a recto-vaginal fistula occurring 30 years after Swenson's operation for Hirschsprung's disease

后矢状肛门直肠成形术治疗 Swenson 先天性巨结肠手术 30 年后发生的直肠阴道瘘

DOI：
发表时间：
2005
期刊：
Acta Med Biol 53
影响因子：
0
作者：
Shinji Tanaka;et al.;窪田正幸;窪田正幸;Naoki Okuyama;Minoru Yagi;Masayuki Kubota;Masayuki Kubota;Naoki Okuyama;窪田正幸;Yagi M;Okuyama N
通讯作者：
Okuyama N

The herbal medicine Rikkunshi-to stimulates and coordinates the gastric myoelectrical activity in post-operative dyspepsic children after gastrointestinal surgery.

草药六君子土刺激和协调胃肠道手术后消化不良儿童的胃肌电活动。

DOI：
发表时间：
2004
期刊：
Pediatr Surg Int 19
影响因子：
0
作者：
Shinji Tanaka;et al.;窪田正幸;窪田正幸;Naoki Okuyama;Minoru Yagi;Masayuki Kubota;Masayuki Kubota;Naoki Okuyama;窪田正幸;Yagi M;Okuyama N;奥山直樹;Masayuki Kubota;Masayuki Kubota;Masayuki Kubota;Minoru Yagi
通讯作者：
Minoru Yagi

Lecture note of Gastrointestinal disease.

胃肠道疾病讲义。

DOI：
发表时间：
2005
期刊：
影响因子：
0
作者：
Shinji Tanaka;et al.;窪田正幸;窪田正幸;Naoki Okuyama;Minoru Yagi;Masayuki Kubota;Masayuki Kubota;Naoki Okuyama;窪田正幸;Yagi M;Okuyama N;奥山直樹;Masayuki Kubota;Masayuki Kubota;Masayuki Kubota;Minoru Yagi;Masahiro Ohtaki;窪田正幸;窪田正幸;Masayuki Kubota
通讯作者：
Masayuki Kubota

Iinuma Y: "Effects of the Herbal Medicine Inchinko-to on Liver Function in Postoperative Patients With Biliary Atresia-A Pilot Study"J Pediatr Surg. 38. 1607-1611 (2003)

Iinuma Y：“草药 Inchinko-to 对胆道闭锁术后患者肝功能的影响 - 初步研究”J Pediatr Surg。