Basic and clinical investigation of the developmental aspects of the pelvic nervous system and anorectal function using electrophysiological techniques.

使用电生理技术对盆腔神经系统和肛门直肠功能的发育方面进行基础和临床研究。

基本信息

批准号：
06671793
负责人：
KUBOTA Masayuki
金额：
$ 1.34万
依托单位：
KYUSHU UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

We have investigeted the developmental aspects of the pelvic nervous system and anorectal function with special reference to the clinical entities related to the pediatric surgery and obtained the following results :1) Basic investigations using a tension-recording techniques.(1) Human studies : we could not found the post-natal development of the enteric nervous system. However, in the study of the aganglionic segment from Hirschsprung's disease, nitric oxide medicated inhibitory response was found in the long-segment type Hirschsprung's desease, while it was not found in any of the cases with short-segment type.(2) Rabbit fetal intestine : A major neurogenic response in fetus was excitatory but it changed to inhibitory response in the post-natal period, which suggested the post-natal development of the inhibitory system in the rabbit enteric nervous system.2) Clinical investigations usign evoked potential recording.(1) Anal canal evoked potential. The generation of the evoked potential was fundamentally related to the age in control children. Its occurrence was decreased in the patients with chronic constipation.(2) Electromyogram of the external anal sphincter. In control children, the onset was elongated in a proportion to age. In patients with Hirschsprung's disease and anorectal malformation, the disturbed electromyogram was obtained in some cases, suggesting the pelvic nerve dysfunction.(3) Evoked potential at the level of the sacral nerve. We obtained the control values of the evoked response to the stimulation of the post-tibial nerve from the 45 control children. In comparison with these normogram, the icteric patients with biliary atresia exhibited the evoked potential abnormalities at the level of pelvic nerve. Examination of the pelvic nerve function was quite useful in the evaluation of the post-operative prognosis and determination of the suitable timing of the liver transplantation.

我们已经研究了骨盆神经系统和厌食功能的发育方面，并特别提及了与小儿手术有关的临床实体，并获得了以下结果：1）使用张力恢复技术的基本研究。（1）人类研究：我们找不到人类研究后肠神经系统的后期发展。 However, in the study of the aganglionic segment from Hirschsprung's disease, nitric oxide medicated inhibitory response was found in the long-segment type Hirschsprung's desease, while it was not found in any of the cases with short-segment type.(2) Rabbit fetal intestine : A major neurogenic response in fetus was excitatory but it changed to inhibitory response in the post-natal period, which suggested the 2）临床研究引起了潜在记录。诱发潜力的产生与对照儿童的年龄从根本上相关。慢性便秘患者的发生。（2）外部肛门括约肌的肌电图。在对照儿童中，发作与年龄的比例伸长。在Hirschsprung病和厌食直肠畸形的患者中，在某些情况下获得了受干扰的肌电图，这表明骨盆神经功能障碍。（3）（3）在sacral神经水平上引起了诱发潜力。我们获得了对45名对照儿童的启发后腹神经刺激的反应的控制值。与这些规范图相比，胆道上闭锁的黄褐色患者在骨盆神经水平上表现出诱发的潜在异常。骨盆神经功能的检查对于评估术后预后和确定肝移植的适当时间的确定非常有用。