Induction of Bone Regeneration by Controlled Release of Osteogenesis/Angiogenesis Factors from Titanium Implants

本研究的目的是建立一种新的技术，通过控制钛种植体中生物活性因子的释放来实现高效的骨再生。我们设计了一种含有释放生物活性因子（b-FGF）的可生物降解材料的钛植入腔体。我们在动物模型中发现该系统可以诱导植入物周围的骨再生。我们还鉴定了成骨诱导肽和小分子，并阐明了这些分子对骨再生的作用机制。

The aim of this study is to establish a novel technology to achieve efficient bone regeneration by controlled release of bioactive factors from titanium implants. We designed a titanium implant chamber which contains a biodegradable material releasing bioactive factor (b-FGF). We found that this system induces bone regeneration around the implant in an animal model. We also identified osteogenesis inducible peptide and small molecule, and elucidated mechanisms of these molecules on bone regeneration.