Exploration of bioactive compounds from traditional medicinal plants in Vietnam

藤黄是一种中等大小的树木，在越南通常用于传统医药用途。在本研究中，我们研究了藤黄提取物在RAW264.7细胞中激活转录因子Nrf2的能力。我们发现藤黄树皮提取物激活Nrf2，导致抗氧化反应元件（anti - response element， ARE）结合活性和ARE转录激活增加。藤黄树皮提取物还可诱导血红素氧化酶-1 （HO-1）蛋白表达，提示藤黄的药物作用可能与激活Nrf2-HO-1信号通路有关。

Garcinia vilersiana is medium size tree and commonly used for traditional medicinal purposes in Vietnam. In this study, we investigated the ability of Garcinia vilersiana extract to activate transcription factor Nrf2 in RAW264.7 cells. We found that Garcinia vilersiana bark extract activates Nrf2, leading to increase in antioxidant response element (ARE) binding activity and transcriptional activation of ARE. Garcinia vilersiana bark extract was also found to induce heme oxygenase-1 (HO-1) protein expression, suggesting that the drug action of Garcinia vilersiana may be attributable to activation of Nrf2-HO-1 signaling.