Physiological functions of lipid signaling molecule-producing enzymes based on their search of partner proteins

本研究对脂质信号分子产生酶PIP5K和PLD的生理功能进行了研究。研究发现，当刺激海马神经元时，PIP5KAMPA661被去磷酸化，并与接头复合体AP-2相互作用，刺激γ受体的内吞，从而导致长期的抑制。另一方面，研究发现PIP5Kα和PIP5Kβ对精子发生有调节作用。最后，有人认为PLD不参与中性粒细胞的功能，如超氧化物的产生和酶的释放，尽管已有报道表明PLD参与了这些中性粒细胞的功能。

In this study, the physiological functions of lipid signaling molecule-producing enzymes, PIP5K and PLD, have been investigated. It was found that PIP5Kγ661 is dephosphorylated upon NMDA stimulation of hippocampal neurons, interacts with the adaptor complex AP-2 and stimulates the endocytosis of AMPA receptors, thereby inducing the long-term depression. On the other hand, PIP5Kα and PIP5Kβ were found to regulate spermatogenesis. Lastly, it was suggested that PLD is not involved in the neutrophil functions, such as superoxide generation and enzyme release, although the involvement of PLD in these neutrophil functions have been reported.