Molecular mechanisms of phospholipid metabolism and cell morphology regulated by small G protein signaling

在本研究中，细胞信号的机制和生理功能通过小G蛋白Arf 6被调查在分子、细胞和整个动物水平上。发现了以下几个方面：（1）Arf 6调节从神经元中提取精子，通过激活脂质激酶PIP 5 K， （2）Arf 6在肝脏和肿瘤血管生成中发挥了关键作用，指标了Arf 6作为抗癌症药物的可能目标，（3）Arf 6调节通过JNK-相互作用蛋白进行神经元提取和分支。

In this study, mechanisms and physiological functions of the cellular signaling through the small G protein Arf6 have been investigated at the molecular, cellular and whole animal levels. It was found that (1) Arf6 regulates retraction of the spine in neurons through activation of the lipid kinase PIP5K・, (2) Arf6 plays critical roles in the development of the liver and tumor angiogenesis, indicating a possible target of Arf6 as the anti-cancer drug, and (3) Arf6 regulates neurite elongation and branching through the JNK-interacting protein.