Neuronal mechanisms for determination of basic respiratory cycle by dual rhythm generators in the medulla

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Two distinct neuronal networks ; the pre-Botzinger complex (pre-BotC) and the parafacial respiratory group (pFRG), in the ventrolateral medulla (VLM) are involved in respiratory rhythm generation. In the present study, we have studied the neuronal mechanisms for determination of basic respiratory rhythm by interaction between these neuron groups. We found that the pFRG is necessary for postnatal survival because of its involvement in rhythm generation and central chemoreception in the neonatal system.