The role of brain molecular chaperone 14-3-3 protein, which regulates the progress of HIV-1 encephalopathy and prion disease
The role of brain molecular chaperone 14-3-3 protein, which regulates the progress of HIV-1 encephalopathy and prion disease
批准号:
19500308
负责人:
YANO Mihiro
金额:
$2.91万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2008
中文摘要
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英文摘要
エイズ脳症発症のメカニズムを明らかにするため、ヒト脳微小血管内皮細胞(HBMEG)培養系の簡易血液脳関門(BBB)モデルを用いて、H-V-1gp120によるBBB破綻とその制御機構について解析を行った。その結果、14-3-3tが、gp120によるZO-1等のタイトジャンクション(TJ)構成蛋白質のプロテアソームによる分解を防ぐ事で、TJの崩壊に抑制的に機能している事を明らかにした。
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Diclofenac exerts anti-tumor activity via 14-3-3 proteins-dependent activation of mitochondrial apoptosis pathway
双氯芬酸通过 14-3-3 蛋白依赖性激活线粒体凋亡途径发挥抗肿瘤活性
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Hiroshi Endo, Mihiro Yano, Hiroshi Kido]
通讯作者:
Hiroshi Kido
Ibuprofen Increases Cisplatin-induced Apoptosis in Lung Adenocarcinoma By Suooressin2 Hsp70
布洛芬通过 Suooressin2 Hsp70 增加顺铂诱导的肺腺癌细胞凋亡
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[矢野仁康, 遠藤弘史, 木戸博]
通讯作者:
木戸博
The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.
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批准号:20611013
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.83万
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财政年份:2008
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负责人:YANO Mihiro
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依托单位:
The role of anti-apoptotic factor 14-3-3 in HIV-1-associated dementia (HAD) pathology : The implication for the therapy
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批准号:17591044
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.18万
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财政年份:2005
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负责人:YANO Mihiro
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依托单位:
The relationship between a molecular chaperone and protease : The discovery of NDP kinase like activity of a chaperone, and degeneration diseases.
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批准号:14570121
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2002
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负责人:YANO Mihiro
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依托单位:
Discovery of chaperone-type nucleoside diphosphate kinase, a novel function of molecular chaperone proteins, and role of the activity in proteolysis
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批准号:11670128
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:1999
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负责人:YANO Mihiro
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依托单位:
海外基金