The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.
The chemical biology of low side effects compound in anti-fever drugs, which is derived from the analysis about fatal function by diclofenac.
退烧药中低副作用化合物的化学生物学，源于对双氯芬酸致命作用的分析。
批准号：
20611013
负责人：
YANO Mihiro
金额：
$2.83万
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
中文摘要
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英文摘要
To clarify the mechanisms of influenza encephalitis induced by diclofenac, we examined the effect of influenza virus and diclofenac on the disruption of tight junction (TJ) in human vascular endothelial cells in vitro. In this study, we found that influenza virus induced the degradation of TJ proteins, such as ZO1, leading to its disruption. On the other hands, diclofenac by itself inhibited the synthesis of TJ proteins, consequently accelerating the disruption of TJ induced by influenza infection in vascular endothelial cells.
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Role of the host cellular processing proteases in influenza virus infection
宿主细胞加工蛋白酶在流感病毒感染中的作用
宿主细胞加工蛋白酶在流感病毒感染中的作用
DOI：
--
发表时间：
2009
期刊：
影响因子：
--
作者：
[二川健, 他, Yuushi Okumura]
通讯作者：
Yuushi Okumura
DOI：
10.1111/j.1440-1843.2009.01639.x
发表时间：
2009-11-01
期刊：
RESPIROLOGY
影响因子：
6.9
作者：
[Sawabuchi, Takako, Suzuki, Satoshi, Kido, Hiroshi]
通讯作者：
Kido, Hiroshi
Boost of mucosal secretoty immunoglobulin A response by clarithromycin in paediatric influenza.
克拉霉素在小儿流感中增强粘膜分泌性免疫球蛋白 A 反应。
克拉霉素在小儿流感中增强粘膜分泌性免疫球蛋白 A 反应。
DOI：
--
发表时间：
2009
期刊：
Respirology 14(8)
影响因子：
--
作者：
[柴崎忠雄, 他, Takako Sawabuchi]
通讯作者：
Takako Sawabuchi
DOI：
10.1086/656044
发表时间：
2010-10-01
期刊：
JOURNAL OF INFECTIOUS DISEASES
影响因子：
6.4
作者：
[Wang, Siye, Le, Trong Quang, Kido, Hiroshi]
通讯作者：
Kido, Hiroshi
DOI：
10.1371/journal.pone.0007870
发表时间：
2009-11-17
期刊：
PloS one
影响因子：
3.7
作者：
[Kam YW, Okumura Y, Kido H, Ng LF, Bruzzone R, Altmeyer R]
通讯作者：
Altmeyer R
共 28 条
The role of brain molecular chaperone 14-3-3 protein, which regulates the progress of HIV-1 encephalopathy and prion disease
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批准号：19500308
-
项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.91万
-
财政年份：2007
-
负责人：YANO Mihiro
-
依托单位：
The role of anti-apoptotic factor 14-3-3 in HIV-1-associated dementia (HAD) pathology : The implication for the therapy
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批准号：17591044
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项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.18万
-
财政年份：2005
-
负责人：YANO Mihiro
-
依托单位：
The relationship between a molecular chaperone and protease : The discovery of NDP kinase like activity of a chaperone, and degeneration diseases.
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批准号：14570121
-
项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.56万
-
财政年份：2002
-
负责人：YANO Mihiro
-
依托单位：
Discovery of chaperone-type nucleoside diphosphate kinase, a novel function of molecular chaperone proteins, and role of the activity in proteolysis
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批准号：11670128
-
项目类别：Grant-in-Aid for Scientific Research (C)
-
资助金额：$2.56万
-
财政年份：1999
-
负责人：YANO Mihiro
-
依托单位：
海外基金