The role of PPAR in metabolic syndrome with novel genetically modified rabbits

我们产生了转基因（Tg）兔作为一种新的人类代谢综合征疾病模型。PPAR-gamma被认为与其病理状态有关。Tg兔被设计成在其脂肪组织中特异性过表达人PPAR-gamma。结果证实转基因mRNA在转基因兔脂肪组织中有特异性表达，但未发现转基因兔与野生型兔之间的表型差异（病理状态）。认为今后需要进行更详细的进一步检查，如表现蛋白活性。

We generated transgenic (Tg) rabbits as a novel human disease model for metabolic syndrome. PPAR-gamma has been believed to be associated with pathologic status of it. Tg rabbits was designed to specifically overexpress human PPAR-gamma in their adipose tissue. As the results, we confirmed specific expression of mRNA of transgene in the adipose tissue of Tg rabbits, however, we could not find phenotypic differences (pathologic status) between Tg rabbits and wild type one. It is thought that more detailed further examination such as manifestation protein activity is required in future.