Study of sentinel node detection method using contrast-enhanced ultrasonography with second generation of ultrasound contrast agent in malignant tumor

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This study aimed to evaluate the usefulness of sentinel lymph node (SLN) detection in breast cancer using contrast-enhanced ultrasonography with Sonazoid. More than 100 breast cancer patients were examined in our hospital. After 2 ml of Sonazoid was injected subareolarly, the axillary area was observed transdermally using ultrasonography with linear transducer. A contrast-enhanced SLN was seen within 5 min, and its detection rate was more than 80%. Moreover the SLN detection rate was compared with that of other methods and resected SLNs were evaluated pathologically. It is suggested that our new method is clinically useful for sentinel node identification.