Study of sentinel node detection method using contrast-enhanced ultrasonography with second generation of ultrasound contrast agent in malignant tumor

第二代超声造影剂超声造影在恶性肿瘤中前哨淋巴结检测方法的研究

• 批准号: 19500424
• 负责人: OMOTO Kiyoka
• 金额: $ 2.83万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19500424/
• 关键词: 第2世代超音波造影剤; ソナゾイド; センチネルリンパ節; 乳癌; 超音波造影法; 超音波造影剤; 造影超音波画像; 臨床研究; 次世代超音波造影剤; 悪性腫瘍; 腋窩リンパ節郭清

This study aimed to evaluate the usefulness of sentinel lymph node (SLN) detection in breast cancer using contrast-enhanced ultrasonography with Sonazoid. More than 100 breast cancer patients were examined in our hospital. After 2 ml of Sonazoid was injected subareolarly, the axillary area was observed transdermally using ultrasonography with linear transducer. A contrast-enhanced SLN was seen within 5 min, and its detection rate was more than 80%. Moreover the SLN detection rate was compared with that of other methods and resected SLNs were evaluated pathologically. It is suggested that our new method is clinically useful for sentinel node identification.

本研究旨在评价索那唑超声造影检测乳腺癌前哨淋巴结(SLN)的价值。在我们医院检查了100多名乳腺癌患者。乳晕下注射索那唑2ml后，用线阵超声探头经皮观察腋窝部位。5min内可见增强扫描的SLN，其检出率可达80%以上。并与其他方法进行比较，并对切除的SLN进行病理学评价。提示我们的新方法对前哨节点的识别具有临床应用价值。

项目成果

SENTINEL NODE DETECTION METHOD USING CONTRAST-ENHANCED ULTRASONOGRAPHY WITH SONAZOID IN BREAST CANCER: PRELIMINARY CLINICAL STUDY

• DOI: 10.1016/j.ultrasmedbio.2009.02.004
• 发表时间: 2009-08-01
• 期刊: ULTRASOUND IN MEDICINE AND BIOLOGY
• 影响因子: 2.9
• 作者: Omoto, Kiyoka;Matsunaga, Hiroaki;Kawano, Mikihiko
• 通讯作者: Kawano, Mikihiko

ソナソイドを用いた造影超音波法による乳癌センチネルリンパ節同定法の研究

Sonasoid超声造影识别乳腺癌前哨淋巴结方法的研究

• 发表时间: 2008
• 作者: 尾本きよか;竹夏樹;松永宏明;谷口信行;穂積康夫;竹原めぐみ;尾本和;河野幹彦;尾本きよかほか
• 通讯作者: 尾本きよかほか

Sentinel lymph node identification method using contrast-enhanced ultrasonography with Sonazoid^<TM> in breast cancer

使用 Sonazoid^<TM> 超声造影识别乳腺癌前哨淋巴结的方法

• 发表时间: 2009
• 作者: 尾本きよか;竹夏樹;松永宏明;谷口信行;穂積康夫;竹原めぐみ;尾本和;河野幹彦
• 通讯作者: 河野幹彦