Studies on the mechanism underlying stress-induced anorexia

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We studied the mechanism underlying stress-induced anorexia by measuring brain serotonin (5-HT), the locomotor activity, the intakes of food and water, and the nitric oxide (NO) in rats and mice. Immobilization, electric stimulation and alcohol administration were used as stress. The stress caused the dysfunction of 5-HT3 and 5-HT4 receptors. These stresses during active stage in a day significantly decreased the contents of food intake and the locomotor activity. Further, higher level of blood glucose concentration, which was induced by diabetes mellitus, reduced the resistance for the stress, while the relation between the resistance for stress and NO remains obscure.